Chapter
Metabolic Syndrome and Related Disorders
Geographical Distribution
Metabolic Syndrome in Children and Adolescents
Subclinical Inflammation and Endothelial Dysfunction in the Metabolic Syndrome
Subclinical Inflammation and Metabolic Syndrome
Obesity and Subclinical Inflammation
Revising the Definition of Metabolic Syndrome
Management of the Metabolic Syndrome
Case Study Subclinical Inflammation and Endothelial Dysfunction in the Metabolic Syndrome
Discussion of Patient Profiles
Non-Alcoholic Fatty Liver Disease
Epidemiology of Non-Alcoholic Fatty Liver Disease
Pathophysiology of Non-Alcoholic fatty Liver Disease
Pathophysiology of Non-Alcoholic Fatty Liver Disease: Dietary Fat and Hepatic Lipids
Insulin Resistance And Non-Alcoholic Fatty Liver Disease
Asian-Indians, Insulin Resistance, and Non-Alcoholic Fatty Liver Disease
Non-Alcoholic Fatty Liver Disease and Atherosclerosis
Diagnosis of Non-Alcoholic Fatty Liver Disease
Management of Non-Alcoholic Fatty Liver Disease
Glycemic Index (GI) and Fiber
Miscellaneous Drugs (Table 3)
Suggested Recommendations
Case Study Non-Alcoholic Fatty Liver Disease
Obesity and Metabolic Syndrome
Variations in Body Fat and Fat-free Mass among Populations (Table 1)
Cardiovascular Risk Factor Profile and Metabolic Syndrome Indicators, BMI and Body Fat
Ethnic Differences in the Metabolic Syndrome and Body Fat in Children and Adolescents
Prevalence of Obesity in India
Obesity in Children/Adolescents
Body Composition of Asian-Indians and Phenotype Obesity
Truncal and Abdominal Adiposity
Deposition of Fat at Ectopic Sites
Other Ectopic Sites of Fat Deposition
Prediction Equations and Cut-offs of Fat Depots
Cut-offs for Abdominal Adipose Tissues
Revised Guidelines for Body Mass Index and Waist Circumference
Obesity and Metabolic Syndrome
Case Study Obesity and Metabolic Syndrome
Hypertension and Metabolic Syndrome
Definition of Metabolic Syndrome
Mechanism of Hypertension in the Metabolic Syndrome
Obesity and Adipose Tissue Cytokines
Sympathetic Nervous System and Renin-Angiotensin System Overactivity
Prognostic Value of the Metabolic Syndrome in Hypertension
Management of Hypertension in the Presence of Metabolic Syndrome
Targeting the Mechanisms of Metabolic Syndrome
The Dyslipidemia of the Metabolic Syndrome
Normal Cholesterol Metabolism
Dyslipidemia of the Metabolic Syndrome
Therapy of the Dyslipidemia of the Metabolic Syndrome
Cardiovascular Risk and Evaluation
CVD Risk in Metabolic Syndrome
Should Metabolic Syndrome be Given Importance as a Cardiovascular Risk Marker?
Ten-year Risk Versus Lifetime Risk
Cardiovascular Risk Evaluation in Individuals with Metabolic Syndrome
Subclinical Atherosclerosis
Carotid Intima Media Thickness
Brachial Artery Flow-mediated Dilatation
Role of Subclinical Atherosclerosis Testing in Metabolic Syndrome
Cardiovascular Risk and Evaluation
How Should His Cardiovascular Risk be Assessed?
Prevention of Cardiovascular Disease
Clinical Diagnosis Of Metabolic Syndrome
Metabolic Syndrome And Cardiovascular Disease
Prevention Of Cardiovascular Disease In Metabolic Syndrome
Management of Underlying Risk Factors
Physical Activity Recommendations for Healthy Adults Aged 18–65 Years—200715
Atherogenic and Diabetogenic Diets
AHA 2006 Diet and Lifestyle Recommendations for Cardiovascular Disease Risk Reduction13
Management of Dyslipidemia
Stress, Depression and Metabolic Syndrome
Pathophysiological Effects of Chronic Stress
Sequelae of Hypothalamic-Pituitary-Adrenocortical Dysfunction Over Time
Potentiation of Insulin Effect and Insulin Resistance
Stress-Induced Insulin Resistance
Insulin and Leptin Resistance, and Increased Sympathetic Tone
The Renin-Angiotensin-Aldosterone System
Co-Existence of Diabetes and Psychiatric Illness: Indian Perspective
Psychiatric Co-Morbidity in Type 1 Diabetes Mellitus
Worldwide Burden of Depression
Effect of Depression on Glycemic Control and Risk for Diabetes Complications
Effect of Depression on Medication Adherence
Effect of Depression on Diabetes Self-Care Behaviors (TABLE 4)
Effect of Depression on Mortality (TABLE 5)
Causal Pathways Between Diabetes and Depression
Evaluation Methods of Co-morbid Depression in Patients of Diabetes Mellitus
Immediate Memory and Attention
Stroop Test and Digit Symbol Substitution test (DSST)
Correlation of Depression With Glycemic Control
Review of Depression Treatment Interventions in Individuals who Have Diabetes
Barriers to Effective Treatment of Depression in Individuals who Have Diabetes
Improving the Quality of Care: The Need For Integrated Care
The Best Treatment for Depression in Diabetes
Psychological Interventions
Pharmacological Interventions
What do we Need to Know to Improve Treatment of Depression in Diabetes?
Ongoing Research on Depression Treatment in Diabetes
Metabolic Syndrome in Children
Relationship Of Pediatric Metabolic Syndrome With Adult Outcomes
Pathophysiologocal Mechanisms Underlying Pediatric Metabolic Syndrome
Childhood Obesity and Body Fat Patterning
Adipocytokines and Subclinical Infl ammation
Other Factors Related to Metabolic Syndrome in Children
Screening For Metabolic Syndrome In Children And Adolescents
Management Of Metabolic Syndrome In Children
Diet and Physical Activity
Drug Therapy of Metabolic Syndrome