HEPATIC INSULIN RESISTANCE AND NONALCOHOLIC FATTY LIVER DISEASE

HEPATIC INSULIN RESISTANCE AND NONALCOHOLIC FATTY LIVER DISEASE

Library of Congress Cataloging-in-Publication Data

Contents

Preface

Introduction

Chapter I: Triglyceride Storage Regulation in Hepatocytes

Chapter II: Impairment of Fatty Acid Oxidation

Chapter III: NAFLD and Its Progression to NASH and Cirrhosis

Chapter IV: Steatosis

Chapter V: Inflammation

Chapter VI: Fibrosis and Myofibroblastic Cell Differentiation

Chapter VII: Methods of Diagnosis

Liver Biopsy and Quantitative Methods

Clinical Features and Laboratory Tests

New Biomarkers

Panel Markers

Hepatic Imaging

Ultrasonography

Computed Tomography

Magnetic Resonance Imaging

Chapter VIII Rodent NAFLD and NASH Models

Genetically Modified Mice Models

Mice or Rat Models with Naturally Occurring Mutations

Mice with Targeted Gene Deletion for Regulating Fatty Acid Oxidation

Mice with Naturally Occurring Mutations that Inhibit Fatty Acid Oxidation

Normal Mice or Rats Models with Environmentally Induced Hepatic Lipogenesis

Normal Mice or Rats with Environmental Inhibition of Hepatic Fatty Acid Oxidation

References

Index

Chapter IX: Conclusions