Chapter
Analysis and Quantification of Secondary Metabolites in Natural Matrixes and Its Products
Gas-Chromatography and Liquid Chromatography
The Quality by Design (QbD) Approach to the Development of Modern Phytomedicines
How to Develop Phytomedicines Ensuring Internationally Harmonized Quality?
QbD Application to Phytopharmaceuticals
The Importance of Experimental Design in the Standardization for Developing Analytical Methodologies
Location of Experimental Design within the Methodology to Develop and Standardize Analytical Methods
Analytical Target Profile (ATP)
Critical Quality Attributes (CQAs)
Optimization and Development Method with DOE
Method Operable Design Region (MODR)
Control Strategy and Risk Assessment
Continuous Method Monitoring (CMM)
Development of Analytical Methodologies
Brief Observations on Chromatography
Technical Terms of Chromatography
Experimental Design Applications to Standardize the Development of Analytical Methodologies
The Extraction of Bioactives from Plants
Counter Current and Other Moving Bed Extractors
Supercritical Fluid Extraction
Recent Developments in Drying Extracts
Fundamental Aspects: Drying Pharmaceutical Products
Dry Bulb and Wet Bulb Temperature
Bound and Unbound Moisture
Equilibrium Moisture Content and Sorption Isotherms
Behavior of Solids During the Drying Process
Classification of Drying Operations
Selecting Drying Equipment
Spray Freeze Dryer and Fluid Bed Atmospheric Spray Freeze Drying
Excipients for Dried Medicinal Extracts
Evaluating the Pearson and Spearman Correlations Among the Dried Extracts Characteristics
Recent Development in Preparation Methods of Polymeric Micro/Nanoparticle and Solid Lipid Carries to Phytomedicine
Delivery System of Phytomedicine
Polymeric Micro/Nanoparticles
Emulsion Evaporation Method
High-Pressure Homogenization
High Shear Homogenization or Ultrasonication
Emulsification-Solvent Evaporation
Phase Inversion Temperature (PIT) Method
Recent Developments in Experimental Methods of Liposomal Production
I. General Considerations and Concepts
2. Liposome Structure and Composition
3. Classification and Types of Liposomes
II. Liposomes as Phytomedicines: Liposomes versus Phytosomes
III. Liposome Preparation Methods
1.1. Mechanical Dispersion: Preparation and Hydration of a Thin Lipid Film Followed by Size and Lamellarity Reduction
1.2. Solvent Dispersion: Reverse-Phase Evaporation
1.3. Solvent Dispersion: Solvent Injection
1.4. Detergent Removal via Dialysis
2. Novel Methods of Liposome Production
2.1. Dual Asymmetric Centrifugation Method
2.2. Membrane Contactor Method
2.3. Freeze-Drying Double Emulsion
2.4. Supercritical Fluid Technique
IV. Factorial Design for Liposome Production
Standardization and Quality Control
The Quality and Standardization of
Ash (Total, Sulfated and Insoluble in Acid)
Total Content of Extractives Material
Other Assays: Swelling Indices, Bittering and Foam
Microbiological Parameters
Agrochemicals and Pesticides
The Analyses of Chemical Markers
Chromatographic and Spectroscopic Analysis
The Standardization and Quality of
Standardization of Herbal Medicines
Strategies for Herbal Medicines Standardization
The Chemometric Techniques and the Analysis of Complex Mixtures
Principal Component Analysis (PCA) and Cluster Analysis (CA)
Development, Production and Quality Control of Herbal Medicines
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