Cause and Correlation in Biology :A User's Guide to Path Analysis, Structural Equations and Causal Inference

Publication subTitle :A User's Guide to Path Analysis, Structural Equations and Causal Inference

Author: Bill Shipley  

Publisher: Cambridge University Press‎

Publication year: 2002

E-ISBN: 9780511031540

P-ISBN(Paperback): 9780521529211

Subject: Q-332 biological mathematics

Keyword: 生物科学

Language: ENG

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Cause and Correlation in Biology

Description

This book goes beyond the truism that 'correlation does not imply causation' and explores the logical and methodological relationships between correlation and causation. It presents a series of statistical methods that can test, and potentially discover, cause-effect relationships between variables in situations in which it is not possible to conduct randomised or experimentally controlled experiments. Many of these methods are quite new and most are generally unknown to biologists. In addition to describing how to conduct these statistical tests, the book also puts the methods into historical context and explains when they can and cannot justifiably be used to test or discover causal claims. Written in a conversational style that minimises technical jargon, the book is aimed at practising biologists and advanced students, and assumes only a very basic knowledge of introductory statistics.

Chapter

2 From cause to correlation and back

2.1 Translating from causal to statistical models

2.2 Directed graphs

2.3 Causal conditioning

2.4 d-separation

2.5 Probability distributions

2.6 Probabilistic independence

2.7 Markov condition

2.8 The translation from causal models to observational models

2.9 Counterintuitive consequences and limitations of d-separation: conditioning on a causal child

2.10 Counterintuitive consequences and limitations of d-separation: conditioning due to selection bias

2.11 Counterintuitive consequences and limitations of d-separation: feedback loops and cyclic causal graphs

2.12 Counterintuitive consequences and limitations of d-separation: imposed conservation relationships

2.13 Counterintuitive consequences and limitations of d-separation: unfaithfulness

2.14 Counterintuitive consequences and limitations of d-separation: context-sensitive independence

2.15 The logic of causal inference

2.16 Statistical control is not always the same as physical control

2.17 A taste of things to come

3 Sewall Wright, path analysis and d-separation

3.1 A bit of history

3.2 Why Wright’s method of path analysis was ignored

3.3 d-sep tests

3.4 Independence of d-separation statements

3.5 Testing for probabilistic independence

Case 1: X and Y are both normally distributed and any relationship between them is linear

Case 2: X and Y are continuous but not normally distributed and any relationship between them is only monotonic

Case 3: X and Y are continuous and any relationship between them is not even monotonic

3.6 Permutation tests of independence

3.7 Form-free regression

3.8 Conditional independence

3.9 Spearman partial correlations

3.10 Seed production in St Lucie’s Cherry

3.11 Specific leaf area and leaf gas exchange

4 Path analysis and maximum likelihood

4.1 Testing path models using maximum likelihood

Step 1: Translate the hypothetical causal system into a path diagram

Step 2: Translate the causal model into an observational model in the form of a set of structural equations

Step 3: Derive the predicted variance and the covariance between each pair of variables in the model using covariance algebra

Step 4: Estimate the free parameters by minimising the difference between the observed and predicted variances and covariance

Step 5: Calculate the probability of having observed the measured minimum difference, assuming that the observed and…

Step 6: If the calculated probability is sufficiently small (say below 0.05) then one concludes that the model was wrong. If…

4.2 Decomposing effects in path diagrams

Ancestor–descendant relationships

4.3 Multiple regression expressed as a path model

4.4 Maximum likelihood estimation of the gas-exchange model

5 Measurement error and latent variables

5.1 Measurement error and the inferential tests

5.2 Measurement error and the estimation of path coefficients

5.3 A measurement model

5.4 The nature of latent variables

5.5 Horn dimensions in Bighorn Sheep

5.6 Body size in Bighorn Sheep

5.7 Name calling

6 The structural equations model

6.1 Parameter identification

6.2 Structural underidentification with measurement models

6.3 Structural underidentification with structural models

6.4 Behaviour of the maximum likelihood chi-squared statistic with small sample sizes

6.5 Behaviour of the maximum likelihood chi-squared statistic with data that do not follow a multivariate normal distribution

Univariate skew

Univariate kurtosis

Multivariate measures of skew and kurtosis

6.6 Solutions for modelling non-normally distributed variables

6.7 Alternative measures of ‘approximate’ fit

6.8 Bentler’s comparative fit index

6.9 Approximate fit measured by the root mean square error of approximation

6.10 An SEM analysis of the Bumpus House Sparrow data

7 Nested models and multilevel models

7.1 Nested models

7.2 Multigroup models

7.3 The dangers of hierarchically structured data

7.4 Multilevel SEM

8 Exploration, discovery and equivalence

8.1 Hypothesis generation

8.2 Exploring hypothesis space

8.3 The shadow’s cause revisited

8.4 Obtaining the undirected dependency graph

8.5 The undirected dependency graph algorithm

8.6 Interpreting the undirected dependency graph

Directed versus undirected paths

Inducing paths

8.7 Orienting edges in the undirected dependency graph using unshielded colliders assuming an acyclic causal structure

8.8 Orientation algorithm using unshielded colliders

8.9 Orienting edges in the undirected dependency graph using definite discriminating paths

8.10 The Causal Inference algorithm

8.11 Equivalent models

8.12 Detecting latent variables

8.13 Vanishing Tetrad algorithm

8.14 Separating the message from the noise

8.15 The Causal Inference algorithm and sampling error

8.16 The Vanishing Tetrad algorithm and sampling variation

8.17 Empirical examples

8.18 Orienting edges in the undirected dependency graph without assuming an acyclic causal structure

8.19 The Cyclic Causal Discovery algorithm

8.20 In conclusion ...

Appendix

References

Index

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