The Paroxysmal Disorders

Author: Bettina Schmitz; Barbara Tettenborn; Donald L. Schomer  

Publisher: Cambridge University Press‎

Publication year: 2010

E-ISBN: 9780511921926

P-ISBN(Paperback): 9780521895293

Subject: R748 child neurology

Keyword: 神经病学与精神病学

Language: ENG

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The Paroxysmal Disorders

Description

The paroxysmal disorders present neurologists and other medical professionals with diagnostic problems across a range of disorders, including multiple sclerosis, migraine and epilepsy. This new English language edition of a compendium of the paroxysmal disorders, originally published in German as Paroxysmale Störugen in der Neurologie, is an informative and practical resource for clinicians, which provides invaluable help with differential diagnosis and management. Fully updated throughout, this new edition comprehensively covers the entire spectrum of the paroxysmal disorders, including sudden falls, headache, vertigo attacks, memory loss, visual disturbances, seizures and anxiety. Each chapter is practice oriented, covering definitions, etiology, epidemiology, diagnosis, examination techniques and therapy. Detailed guidelines for gathering case-histories, essential for accurate diagnosis, are also provided. Important reading for clinicians, professionals and academic researchers working in neurology, psychiatry, epilepsy, internal medicine and ENT.

Chapter

3 Syncope

Definition

Epidemiology

Diagnosis

“Fainting” as symptom

Clinical phenomenology of syncope

Precipitants and precedents

Phenomena during syncope

Postictal phase

Interaction between syncopal and epileptic mechanisms

Presyncope

Causes of syncope

Reflex-mediated syncope

Neurally mediated or neurocardiogenic, vasovagal syncope

Situational syncope

Carotid sinus syndrome

Orthostatic syncope

Hypoadrenergic orthostatic hypotension

Postural tachycardia syndrome

Hyperventilation syncope

Cardiac syncope

Structural heart diseases with reduced cardiac output

Arrhythmias

Drug-induced syncope

Syncope in neurological disorders

Syncope in psychiatric disorders

Syncope of unknown etiology

Specific examination techniques

Diagnostics of syncope

Initial evaluation

Further diagnostic approach to syncope of unknown etiology

Examination methods

Medical history

Physical examination

Measurements of blood pressure and heart rate

ECG

Carotid sinus pressure test

Tilt-table test

EEG

Cardiologic diagnostic procedures

Differential diagnosis

Other epileptic seizures

Falls, drop attacks and cataplexy

Transient ischemic attacks

Hypoglycemia

Psychogenic non-epileptic seizures

Therapy

Prognosis

References

4 Sudden falls

Overview

Syncope

Drop attacks

Cataplexia

Startle diseases

Extrapyramidal movement disorders

Normal-pressure hydrocephalus

Non-epileptic seizures

Epileptic seizures and epilepsies

Seizures that may result in falls

Absences

Myoclonic seizures

Generalized tonic-clonic seizures

Primary generalized tonic-clonic seizures

Secondary generalized tonic-clonic seizures

Focal seizures

Mesial temporal lobe epilepsy

Lateral temporal lobe epilepsy

Frontal lobe epilepsy

Parietal or occipital lobe epilepsy

Falls in focal seizures

Secondary generalization

Seizures defined by falls: epileptic drop attacks

Generalized tonic seizures

Atonic and myoclonic astatic seizures

Startle epilepsies

Falls as a side-effect of anti-epileptic medication

Treatment of epileptic drop attacks

Drug therapy

Resective epilepsy surgery

Palliative epilepsy surgery

Vagal nerve stimulation

Callosotomy

References

5 Paroxysmal headaches

Definition

Epidemiology

Diagnosis

Differential diagnosis

Pathophysiology

Therapy

Therapy of a migraine attack

5-HT 1B/1D-agonists (triptans)

Comparison of triptans

Ergot alkaloids

Antiemetics and simple analgesics

Analgesics (NSAIDs)

Preventive treatment of migraine

Substances for preventive migraine therapy

Non-medical migraine prophylaxis

Behavioral therapy

Cluster headaches

Definition and epidemiology

Clinical symptoms

Differential diagnosis

Pathophysiology

Therapy

Chronic paroxysmal hemicrania

Other paroxysmal headaches

Trigeminal neuralgia

Definition, epidemiology and clinical symptoms

Pathophysiology

Drug therapy

References

6 Paroxysmal vertigo attacks

Peripheral vestibular vertigo syndromes

Benign paroxysmal positioning vertigo (BPPV)

Definition

Epidemiology

Diagnosis

Differential diagnosis

Pathophysiology

Therapy

Physical liberatory maneuvers

Surgery

BPPV of the horizontal canal

Therapy

Menières disease

Definition

Epidemiology

Diagnosis

Differential diagnosis

Pathophysiology

Therapy

Treatment of attacks

Prophylactic therapy

Treatment of vestibular drop attacks

Perilymph fistulas

Definition and epidemiology

Diagnosis

Differential diagnosis

Therapy

Conservative therapy

Surgical therapy

Vestibular paroxysmia

Neurovascular cross-compression of the VIIIth cranial nerve

Definition and epidemiology

Diagnosis

Differential diagnosis

Pathophysiology

Therapy

Central vestibular forms of vertigo

Vestibular migraine

Definition and epidemiology

Diagnosis

Differential diagnosis

Pathophysiology

Therapy

Vertebrobasilar ischemia

Central vestibular syndromes in the three planes of action of the vestibulo-ocular reflex

References

7 Paroxysmal visual disturbances

Vision in the blind field

Delusions

Visual illusions

Visual perseveration

Immediate perseveration

Palinopsia

Case report

Hallucinatory palinopsia

Visual perseveration and epilepsy

Polyopia

Monocular diplopia

Visual hallucinations

Photopsias

Photopsias in migraine

Case report

Photopsias in the hemianopic field

Case report

Complex hallucinations

Complex hallucinations and epilepsy

Case report

Charles Bonnet syndrome

Peduncular hallucinations

Complex hallucinations in the hemianopic field

Hypnagogic and respectively hypnopompic hallucinations

Literature

References

8 Paroxysmal paresis

Localized paroxysmal paresis

Hemiparesis or hemiplegia

Topodiagnosis

Cortical and subcortical lesions

Lesions in the internal capsule

Brain stem lesion

Spinal lesion

Ischemia

Clinical findings

Diagnostic procedures

Rare causes

Therapy

Treatment of the risk factors

Thrombocytic aggregation inhibitors

Anticoagulation

Carotid endarterectomy

Vascular malformations and space-occupying lesions

Sinus- and cerebral-vein thrombosis

Encephalitis

Metabolic disturbances

Migraine

Postictal paresis

Ictal paresis

Multiple sclerosis

Alternating hemiplegia of childhood

Paraparesis or paraplegia

Topodiagnosis

Spinal lesion

Parasagittal lesion

Spinal ischemia

Spinal bleeding

Myelitis

Spinal space-occupying lesion

Epidural abscess

Disc prolapse

Cervical myelopathy

Tetraparesis or tetraplegia

Topodiagnosis

Spinal lesions

Brain stem lesion

Differential diagnosis of paroxysmal tetraparesis

Ischemia

Drop attacks

Disc prolapse

Polyneuroradiculitis

Monoparesis/Monoplegia

Topodiagnosis and differential diagnosis of paroxysmal monoparesis

Acute double vision

Peripheral facial nerve palsy

Subclavian steal syndrome

Compression syndromes in anatomical narrowings

Latent compartment syndrome

Thoracic outlet syndrome

Neuralgic amyotrophy (brachial neuropathy)

Acute nerve root compression

Diagnosis and therapy

Functional pareses

Generalized paroxysmal motor weakness (paresis)

Myasthenia gravis

Pathophysiology

First aid pocedures

Lambert-Eaton syndrome

Muscular weakness due to toxic influence on the motoric endplate

Botulism

Cataplexy and sleep paresis

Episodic pareses

Diseases of the sodium channel

Paramyotonia congenita

Hyperkalemic episodic paresis

Therapy and Course

Diseases of the calcium channels

Hypokalemic episodic paresis

Diagnosis

Therapy and course of disease

Normokalemic periodic paresis

Muscular weakness due to electrolyte disturbance

Metabolic myopathies

Glycogenose type V (muscle phosphorylase deficiency, McArdles disease)

Glycogenose type VII (phosphofructokinase-deficiency, Tarui disease)

Differential diagnosis

Therapy

Endocrine myopathies

Thyrotoxic episodic weakness (paresis)

Toxic and drug-induced myopathies

Acute alcohol myopathy

Malignant hyperthermia

Malignant neuroleptic syndrome

Inflammatory myopathies

Generalized weakness of non-organic origin

Case history

References

9 Paroxysmal dyskinesias

Introduction

Definition

Diagnosis

Paroxysmal kinesigenic dyskinesia (PKD; DYT10)

Paroxysmal non-kinesigenic dyskinesia (PNKD; DYT8)

Paroxysmal exercise-induced dyskinesia (PED)

Paroxysmal hypnogenic dyskinesia (PHD)

Etiology

Idiopathic paroxysmal dyskinesias

Secondary paroxysmal dyskinesias

Animal models of paroxysmal dyskinesias

Assessment and laboratory work-up in general practice

Differential diagnosis of paroxysmal dyskinesias

Paroxysmal dyskinesia, epilepsy and ion channels

Further differential diagnoses of paroxysmal movement disorders

Case presentations

References

10 Cramps, spasms, startles and related symptoms

Introduction

Cramps

Definition

Epidemiology and general manifestations

Selected diseases

Treatment

Spasms

Definition

Epidemiology and general manifestation

Selected diseases

Exaggerated startle

Epidemiology and general manifestation

Definition

Selected diseases

References

11 Myoclonus

Definition

Epidemiology

Diagnosis, differential diagnosis and classification

Physiological myoclonus in healthy individuals

Essential myoclonus

Epileptic myoclonus

Symptomatic myoclonus

Evaluation and clinical neurophysiology

Therapy

References

12 Paroxysmal memory loss

Transient global amnesia

Definition and clinical presentation

Case Report

Precipitating events

Epidemiology

Diagnosis

Specific examination techniques

Anterograde amnesia

Anterograde memory for verbal material

Anterograde memory for nonverbal material

Retrograde amnesia

Diagnostic imaging

Treatment

Lesion localization

Etiology and pathomechanisms of TGA

Migraine hypothesis

Vascular ischemic hypothesis

Vascular venous hypothesis

Epileptic hypothesis

Benzodiazepine hypothesis

References

13 Dissociative seizures

Introduction

Definition and classification

Epidemiology

Diagnosis

Taking the history

Symptomatology of dissociative seizures

Supportive diagnostic procedures

Post-hoc diagnostic tools

Prolactin

Suggestion

EEG, imaging and neuropsychological findings

Pseudo status epilepticus

Psychiatric co-morbidity

Management and treatment

Prognosis

Case Reports

Psychogenic non epileptic seizures with onset during childhood

Epilepsy in a patient with borderline personality disorder

References

14 Anxiety

Definition and clinical description

Panic disorder

Phobia

Agoraphobia

Social phobia

Specific phobias

Hypochondriasis

Generalized anxiety disorder

Epidemiology of anxiety disorders

Diagnosis, differential diagnosis and co-morbidity of panic-type fear

Diagnosis

Patient perspective

Examiner perspective

Neurological and psychiatric differential diagnosis

Two steps of neurological differential diagnosis

Psychiatric differential diagnosis

Somatoform disorders

Depressive disorder

Co-morbidity of anxiety and organic neurological disease

Therapy

Management of anxiety disorders in a neurological setting

Psychiatric therapy and psychotherapy

References

15 Vegetative seizures

Introduction

Pheochromocytoma

Carcinoid syndrome

Vegetative auras and seizures

Epidemiology

Diagnosis and differential diagnosis

Therapy

Prognosis

References

16 Episodic ataxias

Episodic ataxia type 1 (EA1)

Definition

Epidemiology

Molecular pathogenesis

Clinical features

Diagnosis

Differential diagnosis

Therapy

Natural history

Episodic ataxia type 2 (EA2)

Definition

Epidemiology

Molecular pathogenesis

Clinical features

Diagnosis and differential diagnosis

Laboratory examinations

Differential diagnosis

Therapy

Acetazolamide

4-aminopyridine (4-AP)

Natural history

Other episodic ataxias

Episodic ataxia type 3 (EA3)

Episodic ataxia type 4 (EA4)

Episodic ataxia type 5 (EA5)

Episodic ataxia type 6 (EA6)

Episodic ataxia associated with ATPase6 gene mutation

Sporadic late-onset paroxysmal cerebellar ataxia

Other episodic ataxias

Example case

References

Index

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