Description
Iron Oxide Nanoparticles for Biomedical Applications: Synthesis, Functionalization and Application begins with several chapters covering the synthesis, stabilization, physico-chemical characterization and functionalization of iron oxide nanoparticles.
The second part of the book outlines the various biomedical imaging applications that currently take advantage of the magnetic properties of iron oxide nanoparticles. Brief attention is given to potential iron oxide based therapies, while the final chapter covers nanocytotoxicity, which is a key concern wherever exposure to nanomaterials might occur.
This comprehensive book is an essential reference for all those academics and professionals who require thorough knowledge of recent and future developments in the role of iron oxide nanoparticles in biomedicine.
- Unlocks the potential of iron oxide nanoparticles to transform diagnostic imaging techniques
- Contains full coverage of new developments and recent research, making this essential reading for researchers and engineers alike
- Explains the synthesis, processing and characterization of iron oxide nanoparticles with a view to their use in biomedicine
Chapter
Part 1: Iron Oxide Nanoparticles
Chapter 1: Metal Oxide Particles and Their Prospects for Applications
1.1. Magnetic Metal Oxides
1.2. Metal Oxides With Photoluminescence Properties
1.3. Metal Oxides in Electronics, Catalysis, Gas Sensors and Energy Technologies
1.3.1. Metal Oxide in Electronics
1.3.2. Metal Oxides as Catalysts
1.3.3. Metal Oxides in Gas Sensing
1.3.4. Metal Oxide in Energy Technologies
1.4. Metal Oxides in Biomedical Applications
1.4.1. MRI and Cancer Treatment
1.4.2. Antibacterial Properties
1.4.3. Biomedical Implant
Chapter 2: Iron Oxide Nanoparticles for Biomedical Applications: Synthesis, Functionalization, and Application
2.1. Iron Nanoparticles: Advantages and Limitations for Biomedical Applications
2.2. Synthesis of Iron Oxide Nanoparticles Aimed for Biomedical Applications
2.2.2. Understanding the Nanoparticles Formation
2.2.2.1. General Principle
2.2.2.2. Nucleation/Growth Principle-LaMer Theory
2.2.3. Iron Oxide NPs Synthesis by Wet Chemical Methods
2.2.3.1. Main Wet Chemical Synthesis Methods
2.2.3.2. Thermal Decomposition Synthesis
Control of the Composition
Morphology Control: The Case of Cubes
2.3. Stabilization of the Nanosystems
2.3.2.1. Dendrimer-Stabilized NPs (DSNPs)
2.3.2.2. Dendrimer-Assembled NPs (DANPs)
2.3.2.3. Dendronized Nanoparticles
2.3.3. Nonpolymeric Surface
2.4. Methods of IONPs Functionalization for Biomedical Applications
2.4.1. Functionalization Strategies as a Function of the NPs Synthesis Method
2.4.2. Interaction of Molecules With the Surface of Iron Oxide NPs: Importance of Anchoring Groups
Part 2: Biomedical Applications
Chapter 3: Protein Corona: The Challenge at the Nanobiointerfaces
3.3. "Hard" Versus "Soft" Corona
3.4. Reversible Versus Irreversible Interactions Between NPs and Proteins
Chapter 4: Nanocytotoxicity
4.3. Superparamagnetic Iron Oxide Nanoparticles
Chapter 5: Magnetic Particle Imaging (MPI)
5.2. Superparamagnetic Iron Oxide Nanoparticles for MPI
5.3. Size and Homogeneity
5.4. Iron Oxide Nanoparticle Coatings
Chapter 6: Targeted Iron Oxide (Nano)particles Used as MRI Contrast Agent in Small Animal Models
6.2. MRI of Apoptosis With Iron Oxide-Based Compounds
6.3. MRI of Inflammatory Diseases With Iron Oxide-Based Compounds
6.3.1. Atherosclerosis Plaques
6.3.2. Kidney Inflammation
6.3.3. Brain Inflammation
6.3.4. Inflammation in Other Tissues
6.4. MRI of Tumor Angiogenesis With Iron Oxide-Based Compounds
6.4.1. MRI of Tumor Cells
Chapter 7: Dual-Modality Imaging
7.1. The Necessity of Dual Modality Imaging
7.3. Multimodality Imaging
7.6. Challenges in PET/MRI
Chapter 8: Current Outlook and Perspectives on Nanoparticle-Mediated Magnetic Hyperthermia
8.1. Historical Development and Outlook
8.2. Rationalization of NP Characteristics for MH
8.2.1. Nanoparticle Composition and Particle Anisotropy
8.2.2. Nanoparticle Size: "Go Big or Go"?
8.2.3. Colloidal Stability Effects
8.3. Interparticle Interactions
8.4. Justification for the Use of Iron Oxides in Magnetic Hyperthermia
8.4.1. Gd-Doped Iron Oxides
8.4.2. Transition Metal Doped Iron Oxides
8.4.3. Noble Metal-Iron Oxides Heteronanoparticles
8.5. Other Materials Used and Envisioned for Magnetic Hyperthermia
8.5.1. Lanthanum Strontium Manganites (LSMO)
8.5.2. Substituted Ferrites
8.5.3. Magnetocaloric Materials
8.6. Overview on the Current Instrumentation Available
8.7. Clinical Trials (Past, Present, and Future Ones)
8.8. Other Selected Topics in Magnetic Hyperthermia Research
8.8.1. NP Hyperthermia Activated by Near Infrared Irradiation
8.8.2. "Cold" Hyperthermia
8.8.3. Magnetic Stent Hyperthermia
8.9. Conclusions and Prospects
9.2. Iron Oxide Nanoparticles: Design Considerations
9.4. Physicochemical Considerations
9.8. Directing Nanoparticles In Vivo
9.9. Drug Loading and Release
Chapter 10: Tumor-Targeted Therapy
10.2. Nanotechnology and Cancer Therapy
10.3. Iron Oxide Nanoparticles and Cancer Therapy
Chapter 11: Cancer Therapy
11.2. The Role of Magnetic Iron Oxide in Cancer Therapy
11.3. Diagnostic Imaging and Cancer Therapy
11.3.1. Characteristics of Iron Oxide Nanoparticle-Based Contrast Agents for Cancer Imaging and Therapy
Iron Oxide Nanoparticles for Biomedical Applications
：Synthesis, Functionalization and Application
( Metal Oxides )
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