Description
Selenium and Selenoproteins in Cancer, Volume 136, the latest release in the Advances in Cancer Research series, provides invaluable information on the fast-moving field of cancer research. This updated volume includes chapters on The epidemiology of selenium and human cancer, Selenium, epigenetics and cancer, Selenium status and cancer risk, Nutritional aspects of selenium and breast cancer risk: focus on cellular and molecular mechanisms, Selenoproteins in tumorigenesis and cancer progression, Selenoproteins and metastasis, The tumor microenvironment and inflammatory factors, and Selenium-dependent glutathione peroxidases during tumor development.
This new release in the series presents original reviews on research regarding the prevention and treatment of cancer with selenium.
- Provides information on cancer research and prevention
- Offers outstanding and original reviews on a range of cancer research topics, with this volume focusing on the role of selenium and selenoproteins in cancer prevention
- Serves as an indispensable reference for researchers and students alike
Chapter
2. Selenium and Cancer: Scope of Research
4. Randomized Controlled Trials
5. The Nutritional Prevention of Cancer Trial
6. The Selenium and Vitamin E Cancer Prevention Trial
8. A Natural Experiment on Selenium and Cancer
9. Selenium in Cancer Therapy
Chapter Two: Selenoproteins in Tumorigenesis and Cancer Progression
2. Selenoprotein Production
3. Investigating Selenoproteins Through Sec tRNA Mutations
4. Role of Specific Selenoproteins in Tumorigenesis
4.2. Glutathione Peroxidases
4.3. Thioredoxin Reductases
5. Considerations and Conclusions
Chapter Three: Selenoproteins and Metastasis
2.3. Survival in Vasculature, Extravasation, and Formation of Micrometastases
3. Dietary Selenium and Selenium Supplementation
4. Thioredoxin Reductases and Redox Tone
5. GPX and ROS Regulation
6. Selenoproteins Involved in ER Stress and Calcium Flux
7. Other Potential Roles for Selenoproteins in Metastasis
Chapter Four: Selenium-Dependent Glutathione Peroxidases During Tumor Development
2. Expression Profile of Se-Dependent GPxes in Different Types of Tumors
3. Hydroperoxides and Redox Signaling During Cancer Development
4. Impact of Individual GPxes on Tumor Development
Chapter Five: Targeting the Selenoprotein Thioredoxin Reductase 1 for Anticancer Therapy
1.1. The Thioredoxin System
1.2. Thioredoxin Reductase 1
2. TrxR1 as an Important Enzyme in Cancer
Chapter Six: The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium
1. Tumor Microenvironment: Interplay With Immune Cells and Pathways of Inflammation
2. Selenium-Dependent Effects on Cancer Stem Cells in Leukemia
3. Interaction of LSCs With Immune Cells Mediated by CyPGs
4. Targeting LSC Metabolism With Selenium
Chapter Seven: Selenium and Breast Cancer Risk: Focus on Cellular and Molecular Mechanisms
1. Breast Cancer: General Aspects
2. Se: Nutritional Aspects
3.1. Evidence From Human Studies
3.2. Evidence From Animal Models
3.2.1. Se Chemopreventive Effects
3.2.2. Se Chemotherapy Effects
4. Cellular and Molecular Mechanisms of Se in Breast Cancer Prevention and Treatment
4.4.1. Polymorphisms in Genes Coding Selenoproteins
4.4.2. New Functions of Selenoproteins
4.4.3. Epigenetic Mechanisms
4.4.4. Long-Term Influence of Early-Life Se Exposure on Later Breast Cancer Risk
5. Se Toxic and Procarcinogenic Effects in Breast Cancer
6. Concluding Remarks and Future Perspectives
Chapter Eight: Selenium and Epigenetics in Cancer: Focus on DNA Methylation
2. Selenium and DNA Methylation
2.1. Selenium, DNA Methyltransferase, and Global DNA Methylation
2.2. Selenium and Methylation of Tumor Suppressor Genes
2.3. Possible Mechanisms Underlying Se-Induced DNA Hypomethylation Under Different Levels of Exposure/Intake
3. Methylation of Selenoprotein-Encoding Genes
3.1. Methylation Status in Human Cancer Tissues
3.2. Methylation Status in Human Cancer Cell Lines
Chapter Nine: Selenium and Cancer Stem Cells
2. Selenium, Human Health, and Cancer
3. CSCs: A Debated Theory
4. Cellular Properties of CSCs: Focus on Redox Regulation
5.1. GPx-2 and Other Selenoproteins in CSC Biology
5.2. Targeting the Wnt/β-Catenin Pathway With Se Compounds
5.3. Se Compounds Modulate Arachidonic Acid Metabolism and PPAR-Gamma Activity in CSCs
Chapter Ten: Selenocompounds in Cancer Therapy: An Overview
2. Seleniumo-Containing Molecules in Cancer Therapy
2.1. Inorganic Selenium Species
2.2. Selenium-Containing Amino Acids
2.3. Methylseleninic Acid
2.5. Selenocyanates and Isoselenocyanates
2.7. Selenocarbonyl Derivatives
2.9. Selenazoles and Selenadiazoles
3. Selenium Compounds Mechanism of Action in Tumor Cells
3.1. The Selective Uptake of Se in Cancer Cells
3.2. The Redox-Active Character of Organoselenium Compounds Relevant to Their Anticancer Properties
4. Cell Signaling Pathways Influenced by Se Compounds
4.1. PI3K/Akt and MAPK Pathways
4.2. ER Stress Response to Protein Misfolding
4.3. Angiogenesis and Cancer Progression
4.4. GSTP as Target of Se Organic Anticancer Agents
4.5. Epigenetics of Se Compounds