Title Page

Copyright Page

Contents

Preface

Section 1 Introduction

Chapter 1.1 The Global Burden of Cancer

References

Chapter 1.2 Cancer Staging and Classification

1.2.1 Benign Tumour (or neoplasm)

1.2.2 Malignant Tumour (or cancer)

1.2.3 Tumour Nomenclature and Classification

1.2.4 Cellular Differentiation and Tumour Grade

1.2.5 Tumour Invasion and Metastasis

1.2.6 Clinical Staging of Cancer

References

Chapter 1.3 Cellular and Molecular Basis of Cancer

1.3.1 Oncogenes

1.3.2 Tumour Suppressor Genes

1.3.3 Role of Epigenetics and Gene Promoter Regulation in Tumourigenesis

1.3.4 Multistage Tumourigenesis

1.3.5 Oncogene Addiction

1.3.6 Hallmarks of Cancer

1.3.7 Principles of Cancer Treatment

References

Section 2 The Anticancer Agents

Chapter 2.1 Agents Which Act Directly on DNA

2.1.1 Nitrogen Mustards and Nitrosoureas

References

2.1.2 Temozolomide

References

2.1.3 Platinum-containing agents

References

2.1.4 Gemcitabine

References

2.1.5 Camptothecin and Its Analogues

References

2.1.6 Podophyllotoxins

References

2.1.7 Anthracyclines [1]

References

2.1.8 Epigenetic Targeting Agents [1]

References

Chapter 2.2 Antimetabolites

2.2.1 Cytarabine

References

2.2.2 Methotrexate

References

2.2.3 5-Fluorouracil

References

2.2.4 6-Mercaptopurine

References

Chapter 2.3 Antimicrotubule agents

2.3.1 Taxanes

References

2.3.2 Vinca Alkaloids

References

Chapter 2.4 Anti-hormonal agents

2.4.1 Bicalutamide

References

2.4.2 Tamoxifen

References

2.4.3 Anastrozole [1]

References

Chapter 2.5 Kinase Inhibitors

2.5.1 Discovery

2.5.2 Synthesis

2.5.3 Mode of Action

2.5.4 Mechanism of Resistance [32]

2.5.5 Adverse Drug Reactions

References

Section 3 The Cancers

Chapter 3.1 Breast Cancer

3.1.1 Epidemiology

3.1.2 Presentation

3.1.3 Diagnosis

3.1.4 Staging

3.1.5 Treatments

References

Chapter 3.2 Colorectal cancer

3.2.1 Epidemiology

3.2.2 Presentation

3.2.3 Diagnosis

3.2.4 Staging

3.2.5 Treatments

References

Chapter 3.3 Leukaemia

3.3.1 Epidemiology

3.3.2 Presentation

3.3.3 Diagnosis

3.3.4 Staging

3.3.5 Treatments

References

Chapter 3.4 Lung cancer

3.4.1 Epidemiology

3.4.2 Presentation

3.4.3 Diagnosis

3.4.4 Staging

3.4.5 Treatments

References

Chapter 3.5 Oesophageal Cancer

3.5.1 Epidemiology

3.5.2 Presentation

3.5.3 Diagnosis

3.5.4 Staging

3.5.5 Treatments

References

Chapter 3.6 Ovarian cancer

Key points

3.6.1 Epidemiology

3.6.2 Presentation

3.6.3 Diagnosis

3.6.4 Staging

3.6.5 Treatments

References

Chapter 3.7 Pancreatic Cancer

3.7.1 Epidemiology

3.7.2 Presentation

3.7.3 Diagnosis

3.7.4 Staging

3.7.5 Treatments

References

Chapter 3.8 Prostate Cancer

3.8.1 Epidemiology

3.8.2 Presentation

3.8.3 Diagnosis

3.8.4 Staging

3.8.5 Treatments

References

Chapter 3.9 Skin Cancers

3.9.1 Epidemiology

3.9.2 Presentation

3.9.3 Diagnosis

3.9.4 Staging

3.9.5 Treatments

References

Chapter 3.10 Testicular cancer

3.10.1 Epidemiology

3.10.2 Presentation

3.10.3 Diagnosis

3.10.4 Staging

3.10.5 Treatments

References

Index

EULA