Autism and Environmental Factors

Chapter

Why Is There a “Spectrum” in Autism?

Are Genetic Mutations the Cause of Autism?

ASD Parent and Affected Child Exome Sequencing Display De Novo Mutation

More Than 1,000 Genetic and Genomic Disorders and Still Counting

Why Do Certain Chemicals Induce Specific Depletions of Certain Brain Compartments?

Genesis of an ASD Brain

Pinpointing Critical Steps Where the Autistic Brain Emerges

Is Finding Mutations the Path to Discovering the Genesis of ASD?

Does Brain Size Matter?

How Autism Develops in a Fetal Brain

Why Is There a “Spectrum” in ASD?

ASD and Vaccines

Thimerosal Containing Mercury Stays in the Body and Is Very Toxic

Summary

References

Chapter 2 What is Autism?

Legacy of Autism

A Short History of Autism

DSM-5 and the ASD Spectrum

Changes in ASD diagnosis approved by the APA

The impact of the Recent DSM‐5 Changes on Diagnosis and Support Practices

A New ASD Diagnosis Category: Social Communication Disorder

ASD or a Giant Spectrum of Socioneuropsychological Disorders

Asperger Syndrome

Pervasive Developmental Disorder Not Otherwise Specified

Autistic Disorder

Rett Syndrome

Childhood Disintegrative Disorder

Is Autism a Genetic Disease?

Synthetic Chemicals Lack Coevolutionary Adaptation

Myth of the Genetic Origin of Autism

Phenotypic Heterogeneity in Autism

Why Fragile X Syndrome or Tuberous Sclerosis Should Not Be Included in ASD

Tuberous Sclerosis

Is Finding Mutation the Path to Discovering the Origin of ASD?

How Quickly Does Human DNA Mutate?

What is the Mutation Rate in the Whole Human Genome?

Does Brain Size Matter?

Genetics versus Environment

References

Chapter 3 Olfaction and Autism

How Do We Smell?

Summary and Conclusions

References

Chapter 4 Oxytocin, Arginine Vasopressin and Autism Spectrum Disorder

Oxytocin

Why Oxytocin Therapy May be Important for ASD?

Hormones, Neuropeptide Arginine Vasopressin and Oxytocin in ASD

Development of Oxytocin and AVP Neurons in Various Animals and in Man

Oxytocin and Social Experience in Development

Oxytocin and Developmental Neurological Disorders

Exogenous Oxytocin Treatments in Humans

Intranasal and Intravenous Oxytocin Studies in ASD

Oxytocin Trials in ASD: Beyond the Hype and Hope

Summary and Conclusions

References

Chapter 5 Male Gender Bias and Levels of Male Hormones During Fetal Development

Association between 2D:4D Ratio and Brain Connection Development

Male and Female Estrogen and Testosterone Hormone Regulations

Are there Synthetic Chemicals that Humans Are Not Evolutionarily Exposed To?

Why Male Gender Bias?

Male and Female Brains in a Test Tube

Effects of Three Different Levels of Testosterone on Neuronal Morphology

Molecular Basis of Gender Bias in ASD

References

Chapter 6 Maternal Twins and Male Gender Bias in Autism Spectrum Disorders

The Conundrum of ASD Discordance in Maternal Twins

Role of Environment in Maternal Twins revealed by Numerous Methods under Many Conditions

What Types of Discordance are Observed in Maternal Twins?

Differences in Frontal and Limbic Brain Activation in Monozygotic Twin Pairs Discordant for Severe Stressful Life Events

Structural Connectivity of the Brain of a Child with ASD and That of the Unaffected Identical Twin

Differences in Genomic and Epigenomic Expression in Monozygotic Twins Discordant for Rett Syndrome

Differences in CNV between Discordant Monozygotic Twins with Congenital Heart Defects

History of Autism Becoming a Genetic Disease

Many Diseases That Were Considered Genetic are Being Reassessed

De Novo Mutations

To find a Scientific Analysis of ASD Genesis

What are Neuroblastomas?

What Method Did We Use?

Possible Etiologies of Autism

Epigenetic Explained

Epigenetic Changes and the Environment: How Lifestyle Can Influence Epigenetic Change from One Generation to the Next

Factors Other Than Environment That May Be Contributing to ASD

Older Age of Mother and Increased Risk

Conclusion and Summary

References

Chapter 7 Autism and Exposure to Environmental Chemicals

Contribution of Fragrances to ASD

Effects of Fragrances on Male Oxytocin‐Receptor Positive Neurons

Effects of Fragrances on Female Oxytocin‐Receptor Positive Neurons

How Synthetic Chemicals in Fragrances Affect Fetal Brain Development

Synthetic Musks

How Do Synthetic Musks Get Into the Food Chain?

How Are People Exposed to Synthetic Musks?

Musks in Food

Diethyl Phthalate

Octinoxate

Benzyl Benzoate and Benzyl Salicylate

d-Limonene

α-Pinene

Synthetic EDCs

Why Is It Important To Look at EDCs and Their Potential Effects on Our Next Generations?

Where in Fetal Life Are Androgen Receptors Expressed?

Why Testosterone is Essential for Engineering a Male Brain

Spatial Memory

Anxiety-Related Behavior

Play Fighting and Aggression

Adverse Effects of EDCs and Their Mechanisms of Action

Effects of Testosterone or AR Mimicking EDCs

Early Puberty in Males

Change in Sex Ratio

Effects of EDCs on Neurodevelopmental and Neuroendocrine Systems

EDC Effects on Steroid Hormone Receptors in the Brain

Are the EDCs and other Synthetic Chemicals Depopulating the Human Race?

Summary

References

Chapter 8 Maternal Antibodies to Fetal Brain Neurons and Autism

Link between Damage to the Fetal Brain and Maternal Antibodies: A Double Jeopardy

Are there Examples of Such an Immune Mechanism?

Rh Incompatibility

ABO Incompatibility

Why are Fetal Neuroantigens Immunogenic to the Maternal Immune System?

Is There Any Evidence of a Link Between Synthetic Chemicals Exposure, Neurotoxicity, and Autoimmunity?

The Relationship between Autoimmunity and ASD

The Detection of Fetal Brain Neuroantigens in the Maternal Blood

What are the Functions of the Neuroantigens that are Being Destroyed by the Maternal Antibodies?

Animal Models and Neuroantibodies to Autism

Rhesus Macaques Model

Studies Using Rodent Models

Why Do Some Autistic Children Have Bigger Brains?

Is There a Link between Autoimmunity and Other Forms of Neurodevelopmental or Neurodegenerative Disorders?

A Chicken and Egg Conundrum

Tourette Syndrome [30–32] and Obsessive Compulsive Disorder [33]

Other Contributing Factors in Neuropsychiatric Disorders

Infectious Flu Virus

Influenza Vaccine and Narcolepsy

Other Viral and Nonviral Infections

Blood–Brain Barrier

What is the BBB?

Summary and Conclusions

References

Chapter 9 Vaccines and Autism

Childhood Vaccines and Regressive Autism

Politics Versus Science in the Vaccination Era

A Short Glimpse of the History of Vaccines: Justification for Using Vaccines

What is in the Vaccines?

Thimerosal

What is the Evidence That Organomercurial Vaccines Pose a Higher Risk of Regressive Autism?

Why Thimerosal-Containing Vaccines are Harmful: A Scientific Narrative

How Much Mercury is Given to Children Before the Age of 3 years?

Why Do Only Small Numbers of Children Develop Regressive Autism After Vaccination?

Can Measurements of Abnormal Cytokines Identify Children Who Are at Increased Risk for Regressive ASD?

Summary of Contributing Immunological Factors to ASD

References

Epilogue

References

Index

Supplemental Images

EULA

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