Chapter
Part II GnRH Neuron Development
Chapter 2 Prenatal Development of GnRH Neurons
Chapter 3 Fetal/perinatal Programming Causing Sexual Dimorphism of the Kisspeptin–GnRH Neuronal Network
3.1 Discovery of perinatal programming of the GnRH/gonadotropin‐releasing system by sex steroids in rodents
3.2 Critical periods responsible for sexual dimorphism of the GnRH/gonadotropin‐releasing system
3.3 Sexual dimorphism of kisspeptin neurons and the GnRH‐releasing system in rodents
3.4 Potential mechanisms mediating fetal/perinatal programming of the kisspeptin–GnRH neuronal network in rodents
3.5 Species difference in programming of the kisspeptin–GnRH neuronal network
Chapter 4 Postnatal Development of GnRH Neuronal Function
4.2 Historical perspectives
4.3 Postnatal development of the GnRH system
4.4 The mechanism of the pubertal increase in GnRH release
Part III GnRH Neuron Biology
Chapter 5 Regulation of GnRH Gene Expression
5.1 The Gnrh1 gene and its transcript
5.2 Regulation of Gnrh1 transcription
5.3 Transcription factors regulating Gnrh1 transcription
5.4 Gnrh1 chromatin structure is critical for increased transcription of Gnrh1 during GnRH neuron development
5.5 Gnrh1 transcription regulation by noncoding RNAs
Chapter 6 Morphology of the Adult GnRH Neuron
6.2 Immunolabeling of GnRH peptide
6.3 Transgenics pave the way toward the bigger picture
6.4 Putting the pieces together: visualizing the whole GnRH neuron
Chapter 7 The Anatomy of the GnRH Neuron Network in the Human
7.1 Ethical considerations
7.2 IHC studies of developing human GnRH neurons
7.3 Studying GnRH neuron anatomy in adults with ISH
7.4 IHC studies of human GnRH neurons in adults
Chapter 8 Electrophysiology of Rodent GnRH Neurons
8.1 Historical perspective
8.2 Experimental models and recording configurations used for GnRH neuron electrophysiology
8.3 Overview of the intrinsic properties of GnRH neurons
8.4 Neurotransmission and neuromodulation
Chapter 9 Anatomy and Physiology of GnRH Neurons and Their Control of Pituitary Function in Fish
9.2 Anatomy and ontogeny of GnRH neurons, with special reference to the hypophysiotropic GnRH1 neurons
9.3 Electrophysiology of hypophysiotropic GnRH1 neurons in fish
9.4 Physiological functions of teleost GnRH1 neurons: implications from gene KO animals
Part IV Regulation of GnRH Neuron Function
Chapter 10 Unveiling the Importance of Glia and Vascular Endothelial Cells in the Control of GnRH Neuronal Function
10.1 Defining the functional microunit in the GnRH neuroendocrine network
10.2 Visualizing morphological interactions between GnRH neurons and glial cells
10.3 Evidence for gliotransmission in the GnRH neural network
10.4 Probing function‐related structural plasticity in the GnRH neural network
10.5 Deciphering the cell‐to‐cell communication processes underlying structural plasticity
Chapter 11 Genetic Strategies Examining Kisspeptin Regulation of GnRH Neurons
11.2 The ARC kisspeptin neuron population
11.3 The AVPV/PeN kisspeptin neurons
11.4 Steroidogenic control of GnRH neurons via kisspeptin neurons
11.5 Interrogation of kisspeptin neurobiology
11.6 How comparable is the rodent to the human?
Chapter 12 KNDy Hypothesis for Generation of GnRH Pulses: Evidence from Sheep and Goats
12.2 Anatomical approaches
12.3 Functional approaches: local administration of receptor agonists and antagonists and assessment of MUA
12.4 Integration: the KNDy hypothesis in ruminants and rodents
Chapter 13 Generation of the GnRH Surge and LH Surge by the Positive Feedback Effect of Estrogen
13.2 Historical perspective on the concept of positive feedback and models in rodents
13.3 ER‐expressing neurons in the brain and positive feedback
13.4 Progesterone and positive feedback
13.5 Circadian rhythm and positive feedback
13.6 Special aspects of positive feedback in non‐rodent species
13.7 Strength and duration of the E2 signal and positive feedback
13.8 Multi‐unit recording of neurons and positive feedback
13.9 Positive feedback at the level of the pituitary gonadotropes
Chapter 14 Influence of Stress on the GnRH Neuronal Network
14.2 Neuroendocrine mechanisms underlying the effects of stress on the GnRH system
14.3 Effects of stress on reproductive health
Appendix: a selection of common stress paradigms
Chapter 15 Metabolic Regulation of GnRH Neurons
15.2 Hormonal metabolic cues to GnRH neurons
15.3 Identifying neuronal targets of metabolic hormones
15.4 Functional assessment of putative metabolic pathways to the GnRH neuron
15.5 Animal models of infertility due to nutritional excess
Chapter 16 Seasonal Control of the GnRH Neuronal Network as a Means of Uncovering Novel Central Mechanisms Governing Mammalian Reproduction
16.2 Photoperiodic changes in melatonin and the seasonal control of reproduction
16.3 Methods for the analysis of seasonal changes in the hypothalamus
16.4 Pharmacological approaches to the study of the regulation of seasonal reproduction
Part V GnRH in the Clinic
Chapter 17 Human Genetics of GnRH Neuron Function
17.2 Human phenotypes of early and late pubertal development
17.3 KNDy neurons as the GnRH pulse generator
17.4 Genome‐wide association studies on the age of menarche
17.5 Finding new puberty genes
17.6 Challenges in finding new puberty genes
Chapter 18 Modulators of GnRH Secretion and Therapeutic Applications
The GnRH Neuron and its Control
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