Physiology and Pathology of Drug Hypersensitivity: Role of Human Leukocyte Antigens
( Physiology and Pathology of Immunology )
Publication series ： Physiology and Pathology of Immunology
Author： Gwendolin Simper Alexander A. Celik Heike Kunze-SchumacherRainer Blasczyk and Christina Bade-Döding
Publisher： IntechOpen
Publication year： 2017
E-ISBN: INT6654172133
P-ISBN(Paperback): 9789535136910
P-ISBN(Hardback): 9789535136927
Subject： R392 medical immunology
Keyword： 医学免疫学
Language： ENG
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Physiology and Pathology of Drug Hypersensitivity: Role of Human Leukocyte Antigens
Description
Drug Hypersensitivity reactions can be distinguished in adverse drug events and adverse drug reactions. They represent a major problem in the medical scheme, since they are often underestimated. Pharmacogenetic analysis demonstrated significant associations between emerging hypersensitivity reactions and distinct genes of the HLA complex. HLA-mediated hypersensitivity reactions particularly affect skin and liver, however, impairment of the bone marrow and kidney function could also be observed. These life threatening medical conditions can be attributed to the activation of autologous drug-specific T-cells. Severe drug hypersensitivity reactions that resemble acute GvHD are linked to certain specific HLA alleles. The most common hypersensitivity reactions occur after the treatment of HLA-B*57:01+ HIV patients with abacavir and HLA-A*31:01+ or B*15:02+ epileptic patients with carbamazepine (CBZ).
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