Immuno-Thrombotic Effects of Platelet Serotonin
( Serotonin - A Chemical Messenger Between All Types of Living Cells )
Publication series ： Serotonin - A Chemical Messenger Between All Types of Living Cells
Author： Elmina Mammadova-Bach Maximilian Mauler Attila Braun andDaniel Duerschmied
Publisher： IntechOpen
Publication year： 2017
E-ISBN: INT6523369349
P-ISBN(Paperback): 9789535133612
P-ISBN(Hardback): 9789535133629
Subject： R74 Neurology and Psychiatry
Keyword： 神经病学与精神病学
Language： ENG
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Immuno-Thrombotic Effects of Platelet Serotonin
Description
Platelets transport and store serotonin at a high concentration in dense granules and release it upon activation. Abnormal serotonin concentrations in the blood plasma or increased platelet serotonin release promote the development of thrombosis, sepsis, allergic asthma, myocardial infarction, and stroke. Consequently, experimental data suggest possible benefits of serotonin receptor blockade or inhibition of platelet serotonin uptake in the indicated human diseases. Here, we highlight the current state of basic biological research regarding the role of platelet serotonin in normal and pathophysiological conditions focusing on thrombotic and inflammatory diseases. We also describe the possible clinical applicability of targeting thrombo-immune-modulatory effects of platelet serotonin to treat common health problems.
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