Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways
( Hair and Scalp Disorders )
Publication series ： Hair and Scalp Disorders
Author： Anastasia Nesterova and Anton Yuryev
Publisher： IntechOpen
Publication year： 2017
E-ISBN: INT6300267845
P-ISBN(Paperback): 9789535130970
P-ISBN(Hardback): 9789535130987
Subject： R75 Dermatology and Venereology
Keyword： 皮肤病学与性病学
Language： ENG
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Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways
Description
Signaling pathways that control coordination of hair follicle cells genetic program are the convenient model for explaining the hierarchy of intercellular interactions governing cyclic growth of hair. This chapter describes models of molecular signaling pathways specific to dermal papilla cells from balding human scalp in hair follicle cycle. These models include already published data, as well as information inferred from pathway analysis of microarray data and protein-protein interaction database. Interplay of androgenic-alopecia-related signaling pathways FGF, TGFB, BMP, and WNT, as well as cyclin-dependent kinases signaling, is shown.
Chapter