Therapeutic Angiogenesis: Foundations and Practical Application
( Physiologic and Pathologic Angiogenesis - Signaling Mechanisms and Targeted Therapy )
Publication series ： Physiologic and Pathologic Angiogenesis - Signaling Mechanisms and Targeted Therapy
Author： Pavel Igorevich Makarevich and Yelena Viktorovna Parfyonova
Publisher： IntechOpen
Publication year： 2017
E-ISBN: INT6412166411
P-ISBN(Paperback): 9789535130239
P-ISBN(Hardback): 9789535130246
Subject： R54 in cardiac and vascular diseases (circulatory system)
Keyword： 心脏、血管（循环系）疾病
Language： ENG
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Therapeutic Angiogenesis: Foundations and Practical Application
Description
Angiogenesis as therapeutic target has emerged since early works by Judah Folkman, yet his “holy grail” was inhibiting vascular growth to block tumor nutrition. However, in modern biomedicine, “therapeutic angiogenesis” became a large field focusing on stimulation of blood vessel growth for ischemia relief to reduce its detrimental effects in the tissues. In this review, we introduce basic principles of tissue vascularization in response to ischemia exploited in this field. An overview of recent status in therapeutic angiogenesis is given with introduction to emerging technologies, including gene therapy, genetic modification of cells ex vivo and tissue engineering.
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