Publication series : New Developments in the Pathogenesis of Rheumatoid Arthritis
Author: Codrina Ancuta Cristina Pomirleanu Claudia Mihailov EugenAncuta and Daniela Opris
Publisher: IntechOpen
Publication year: 2017
E-ISBN: INT6317566580
P-ISBN(Paperback): 9789535129691
P-ISBN(Hardback): 9789535129707
Subject: R392 medical immunology
Keyword: 医学免疫学
Language: ENG
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BAFF System in Rheumatoid Arthritis: from Pathobiology to Therapeutic Targets
Description
Recent advances in understanding the multifaceted pathobiology of rheumatoid arthritis have highlighted the pivotal role and continuing crosstalk between activated immune cells, pro-inflammatory cytokines, and matrix-degrading mediators, promoting chronic inflammation as well as irreversible tissue damage within an autoimmune background. B cells are widely recognized as leading players in immune-mediated pathology based on their ability to produce not only different patterns of autoantibodies and driving cytokine synthesis but also as independent antigen-presenting cells and by modulating the specific activation of T cells. Overwhelming evidence emphasized the role of BAFF, a B-cell-activating factor, and BAFF receptors (TACI, BCMA, BAFF-R) in promoting B-cell homeostasis, proliferation, and survival under normal and autoimmune systemic disorders. We systematically reviewed data from literature focusing on BAFF, its homolog molecule APRIL, and BAFF-binding receptors biology, dysregulation of BAFF/BAFF receptor signaling in autoimmune settings, and current status of targeting BAFF/BAFF receptor pathway for rheumatoid arthritis.
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