The Role of Telomeres and Telomere-associated Proteins as Components of Interactome in Cell-signaling Pathways
( Telomere - A Complex End of a Chromosome )
Publication series ： Telomere - A Complex End of a Chromosome
Author： Ekta Khattar and Vinay Tergaonkar
Publisher： IntechOpen
Publication year： 2016
E-ISBN: INT6062562130
P-ISBN(Paperback): 9789535127529
P-ISBN(Hardback): 9789535127536
Subject： R394 medical genetics
Keyword： 医学遗传学
Language： ENG
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
The Role of Telomeres and Telomere-associated Proteins as Components of Interactome in Cell-signaling Pathways
Description
Telomeres represent ends of all eukaryotic chromosomes and serve specialized biological role in maintaining genomic integrity by preventing end fusions and degradation. Various protein complexes associate with telomeres to either protect them from DNA damage machinery or maintain telomere length homeostasis. These protein complex subunits cross talk with a variety of cell-signaling components to either maintain telomere integrity or perform other functions, which are either dependent or independent of telomeres and/or their telomeric role. Mutations in these protein components lead to the development of various human diseases, such as age-related disorders, which occur mainly due to telomere dysfunction or cancer development due to telomerase reactivation. This chapter focuses on the structural and functional aspects of telomeric proteins and their importance in human diseases.
Chapter