Autologous and Allogeneic Stem Cell Transplantation for Treatment of Crohn’s Fistulae
( New Insights into Inflammatory Bowel Disease )
Publication series ： New Insights into Inflammatory Bowel Disease
Publisher： IntechOpen
Publication year： 2016
E-ISBN: INT6154064546
P-ISBN(Paperback): 9789535127543
P-ISBN(Hardback): 9789535127550
Subject： R57 digestive system disease and coeliac disease
Keyword： 消化系及腹部疾病
Language： ENG
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Autologous and Allogeneic Stem Cell Transplantation for Treatment of Crohn’s Fistulae
Description
Up to 20% of patients with Crohn’s disease (CD) may have perianal fistula disease. Classically, surgery has played an important role; in recent years, medical treatment has taken a leading role. Immunosuppressants and biological trea tments have proven beneficial in many patients, but still, the percentage of patients who do not respond remains significant. In this scenario, cell therapy is envisaged as an effective alternative to surgery. The promising preclinical and clinical data that we review below suggest that cell therapy could represent a major advance in the clinical management of this difficult problem.
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