Nrf2 Signaling: An Adaptive Response Pathway for Neurodegenerative Disorders
( A Master Regulator of Oxidative Stress - The Transcription Factor Nrf2 )
Publication series ： A Master Regulator of Oxidative Stress - The Transcription Factor Nrf2
Author： Annalisa Lo Gerfo Lucia Petrozzi Lucia Chico and Gabriele Siciliano
Publisher： IntechOpen
Publication year： 2016
E-ISBN: INT6274365300
P-ISBN(Paperback): 9789535128373
P-ISBN(Hardback): 9789535128380
Subject： Q7 Molecular Biology
Keyword： 分子生物学
Language： ENG
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Nrf2 Signaling: An Adaptive Response Pathway for Neurodegenerative Disorders
Description
Oxidative damage contributes to pathogenesis in many neurodegenerative diseases. As the indicator and regulator of oxidative stress, the nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway has been shown to have dynamic changes and examined for its neuroprotective role in many cases. Nrf2 is emerging as a regulatory protein in neuronal death, since it helps neuronal cells to meet with oxidative insults. In this chapter, we summarize the role of Nrf2 as a master regulator of oxidative stress. Furthermore, we treat some natural and chemical substances able to modulate the Nrf2 pathway and, therefore, their possible use in the neurodegenerative diseases therapeutic treatment.
Chapter