Photodynamic Therapy
( Photomedicine - Advances in Clinical Practice )
Publication series ： Photomedicine - Advances in Clinical Practice
Author： Wei Liu and Hong Cai
Publisher： IntechOpen
Publication year： 2017
E-ISBN: INT6269966420
P-ISBN(Paperback): 9789535131557
P-ISBN(Hardback): 9789535131564
Subject： R44 diagnostics
Keyword： 诊断学
Language： ENG
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Photodynamic Therapy
Description
Photodynamic therapy (PDT) employs light activation of tissue‐localized photosensitizer in an oxygen‐dependent process which initiates oxidative stress, inflammation, and cell death. Photodynamic therapy (PDT) involves the activation of a previously administered photosensitizing agent by visible light to induce tumor necrosis. Photosensitizers are topically applied in the treatment of skin tumors to avoid systemic side effects. The main dermatology indications for topical PDT are superficial nonmelanoma skin cancer and dysplasia, notably superficial basal carcinoma (BCC), Bowen's disease (BD), and actinic keratosis (AK). In this chapter, we evaluated the feasibility and efficacy of aminolevulinic acid (ALA) as a photosensitizer (ALA‐PDT) in combination with CO2 laser in the treatment of dermatological disease from basics to clinic research.
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