Single-Walled Carbon Nanohorn (SWNH) Aggregates Inhibited Proliferation of Human Liver Cell Lines and Promoted Apoptosis, Especially for Hepatoma Cell Lines
( Nanomaterials - Toxicity and Risk Assessment )
Publication series ： Nanomaterials - Toxicity and Risk Assessment
Author： Guoan Xiang Jinqian Zhang and Rui Huang
Publisher： IntechOpen
Publication year： 2015
E-ISBN: INT5938161109
P-ISBN(Paperback): 9789535121435
P-ISBN(Hardback): 9789535121435
Subject： O469 Condensed Matter Physics
Keyword： 凝聚态物理学
Language： ENG
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Single-Walled Carbon Nanohorn (SWNH) Aggregates Inhibited Proliferation of Human Liver Cell Lines and Promoted Apoptosis, Especially for Hepatoma Cell Lines
Description
Research focus: SWNHs (single-walled carbon nanohorns) may be utilized to treat cancer as drug carriers based on their particular structure. But, the effect mechanism of the material itself on liver cells has not been investigated. Research methods used: To answer those questions, the roles of rude SWNHs on the biology functions of human liver normal and cancer cells were studied. Results/findings of the research: The results indicated that SWNHs suppressed growth, proliferation, and mitotic entry of human liver normal and cancer cells, and also pushed cell apoptosis, especially in cancer cells. We had found SWNHs in the lysosomes of L02 cells and in the nuclei of HepG2 cells. It indicated that individual spherical SWNH particles could enter into liver cells. Main conclusions and recommendations: Our results identified that it had different mechanisms between SWNHs and hepatoma cell lines or human normal cell lines. Advanced research about application and mechanisms in the treatment of HCC (hepatocellular carcinoma) by SWNHs should be carried out.
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