Brucella-induced Thrombocytopenia and Bleeding
( Updates on Brucellosis )
Publication series ： Updates on Brucellosis
Author： Ali Akbar Heydari
Publisher： IntechOpen
Publication year： 2015
E-ISBN: INT5989061134
P-ISBN(Paperback): 9789535122111
P-ISBN(Hardback): 9789535122111
Subject： R18 Epidemiology and Preventive Medicine;R51 infectious diseases
Keyword： 传染病,流行病学与防疫
Language： ENG
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Brucella-induced Thrombocytopenia and Bleeding
Description
Mild anemia and leukopenia are the most common hematologic problems of acute brucellosis. Mild thrombocytopenia also occurs, but severe cases are uncommon. Thrombocytopenia occurs because of bone marrow suppression, hypersplenisem, hemophagocytosis, and immunologic destruction of the cells or disseminated intravascular coagulation. In endemic areas, hemorrhagic fevers, hematologic malignancies, as well as idiopathic thrombocytopenic purpura should be considered as differential diagnoses for complicated brucellosis. Thrombocytopenia and bleeding can be improved with antibiotic and hematologic supportive therapy whereas in severe cases corticosteroid therapy or splenectomy might be necessary.
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