Mitochondria of Malaria Parasites as a Drug Target
( An Overview of Tropical Diseases )
Publication series ： An Overview of Tropical Diseases
Author： Kenji Hikosaka Keisuke Komatsuya Shigeo Suzuki and Kiyoshi Kita
Publisher： IntechOpen
Publication year： 2015
E-ISBN: INT5921561283
P-ISBN(Paperback): 9789535122241
P-ISBN(Hardback): 9789535122241
Subject： R18 Epidemiology and Preventive Medicine;R51 infectious diseases
Keyword： 传染病,流行病学与防疫
Language： ENG
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Mitochondria of Malaria Parasites as a Drug Target
Description
Mitochondria are organelle, which is found in most eukaryotic cells, and play an important roll in production of many biosynthetic intermediates as well as energy transduction. Recently, it has been reported that mitochondria contribute to cellular stress responses such as apoptosis and autophagy. These functions of mitochondria are known to be essential for survival and maintenance of homeostasis. The mitochondria of malaria parasites are quite different from those of their vertebrate hosts. Because these differences markedly contribute to drug selectivity, we have focused on the Plasmodium mitochondrion to develop antimalarial drugs. Here we summarize recent advances in our knowledge of the mitochondria of malaria parasites and discuss future prospective antimalarial drugs targeting the parasite mitochondrion.
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