Uncovering the Path to Neurodegeneration from Playingfield to Battlefield ( Traumatic Brain Injury )

Publication series ： Traumatic Brain Injury

Author： Frank Baas and Valeria Ramaglia

Publisher： IntechOpen‎

Publication year： 2014

E-ISBN: INT5709057186

P-ISBN(Paperback): 9789535112228

P-ISBN(Hardback): 9789535112228

Subject： Q189 Neurobiology

Keyword：神经科学

Language： ENG

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Uncovering the Path to Neurodegeneration from Playingfield to Battlefield

Chapter

Chapter 4 Uncovering the Path to Neurodegeneration from Playingfield to Battlefield

1. Introduction

2. Clinical evidence

3. Neuropathological changes

3.1. Gross pathological changes

3.2. Microscopic neuropathological changes

4. The tau hypothesis

5. Inflammatory changes

6. The microglia priming hypothesis

6.1. Transition from resting to primed state

6.2. Transition from primed to active state

7. Therapeutical targets

8. Conclusions and future directions

Abbreviations

Author details

References

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