Chapter 1 Liposomes as Potential Drug Carrier Systems for Drug Delivery

1. Introduction

2. Liposome preparation methods

2.1. Mechanical agitation

2.2. Solvent evaporation

2.2.1. Solubilization of the lipid

2.2.2. Solvent evaporation

2.2.3. Hydration

2.2.4. Obtaining SUVs from MLVs

2.3. Solvent injection

2.3.1. Ethanol injection method

2.3.2. Ether injection method

2.4. Surfactant (detergent) solubilization method

2.5. Loading of drugs in liposome formulations

2.5.1. Encapsulation of hydrophilic drugs

2.5.2. Encapsulation of hydrophobic drugs

3. Stability of liposomes

4. Sterilization of liposomes

5. Characterization of liposomes

6. Clinical applications of liposomes

6.1. Ocular applications

6.2. Pulmonary applications

6.3. Cancer therapy

7. New generation liposomes

8. Conclusion

Author details

References