Chapter 9 An Organ Regeneration Platform for Industrial Production of Hollow Neo-Organs

1. Introduction

2. Tengion’s organ regeneration platform

3. The need for urinary neo-organs

3.1. TE/RM methodologies for bladder replacement and augmentation

3.2. Demonstration of Neo-Bladder formation in large animals

3.3. Neo-bladder replacement in human pediatric patients-1st clinical trials of a neo-organ

3.4. Definition of the cell source used for seeding Neo-Bladders: Adipose

3.5. Other approaches to tissue engineering Neo-Bladders

3.6. Key learnings from development of Neo-Bladder: Factors facilitating commercial viability of organ regeneration platform

4. Neo-urinary conduit: Introduction

4.1. GLP preclinical analysis of de novo neo-urinary conduit formation in a porcine cystectomy model

4.2. Alternate cell sourcing of SMC for seeding of NUC

4.3. Clinical trials of NUC

4.4. Regeneration of muco-cutaneous region at skin-conduit junction

5. The gastro-intestinal tract: Introduction

6. Summary

Author details

References