Roles of Methylation and Sequestration in the Mechanisms of DNA Replication in some Members of the Enterobacteriaceae Family ( The Mechanisms of DNA Replication )

Publication series ： The Mechanisms of DNA Replication

Author： Amine Aloui Alya El May Saloua Kouass Sahbani and Ahmed Landoulsi  

Publisher： IntechOpen‎

Publication year： 2013

E-ISBN: INT0343351724

P-ISBN(Paperback): 9789535109914

P-ISBN(Hardback):  9789535109914

Subject： R394 medical genetics

Keyword： 医学遗传学

Language： ENG

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Roles of Methylation and Sequestration in the Mechanisms of DNA Replication in some Members of the Enterobacteriaceae Family

Chapter

Chapter 12 Roles of Methylation and Sequestration in the Mechanisms of DNA Replication in some Members of the Enterobacteriaceae Family

1. Introduction

1.1. The Dam methyltransferase

1.2. The SeqA protein

1.3. The competition of Dam methylase and SeqA for GATC sites

2. DNA replication

3. DNA methylation by Dam protein

4. DNA sequestration by SeqA protein

4.1. Binding of SeqA to Hemimethylated GATC Sequences

4.2. Effects of seqA disruption on DNA replication

5. Membrane sequestration hemimethylated of oriC

6. Cooperation between “Dam” and “SeqA” in DNA Replication

7. Conclusion

8. Future research

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