DNA Methylation in Aggressive Gastric Carcinoma ( Gastric Carcinoma - New Insights into Current Management )

Publication series ： Gastric Carcinoma - New Insights into Current Management

Author： Chung-Man Leung Kuo-Wang Tsai and Hung-Wei Pan

Publisher： IntechOpen‎

Publication year： 2013

E-ISBN: INT4589652135

P-ISBN(Paperback): 9789535109143

P-ISBN(Hardback): 9789535109143

Subject： R57 digestive system disease and coeliac disease

Keyword：消化系及腹部疾病

Language： ENG

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DNA Methylation in Aggressive Gastric Carcinoma

Chapter

Chapter 9 DNA Methylation in Aggressive Gastric Carcinoma

1. Introduction

2. Clinical features, epidemiology, pathogenesis and progression of gastric cancer

3. Principle of DNA epigenetic modification, DNA methylation and detection

3.1. Genomic DNA methylation/demethylation

3.1.1. DNA methylation

3.1.2. DNA demethylation

3.2. DNA methylation-regulated genes in gastric cancer

3.2.1. Protein coding genes

3.2.2. microRNA

4. Promoter methylation of given genes versus clinical significance and prognostic values and therapeutic applications

4.1. Gene methylation and its impact on clinical outcome in gastric cancer

4.2. Hypermethylation profiling

5. Cirulating DNA methylation as biomarkers

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