Acquired Resistance to Targeted MAPK Inhibition in Melanoma ( Melanoma - From Early Detection to Treatment )

Publication series ： Melanoma - From Early Detection to Treatment

Author： Kavitha Gowrishankar Matteo S. Carlino and Helen Rizos  

Publisher： IntechOpen‎

Publication year： 2013

E-ISBN: INT5085353629

P-ISBN(Paperback): 9789535109617

P-ISBN(Hardback):  9789535109617

Subject： R73 Oncology

Keyword： 肿瘤学

Language： ENG

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Acquired Resistance to Targeted MAPK Inhibition in Melanoma

Chapter

Chapter 7 Acquired Resistance to Targeted MAPK Inhibition in Melanoma

1. Introduction

2. The BRAF kinase and the MAPK pathway

3. Mechanisms of acquired BRAF inhibitor resistance in melanoma

4. Alterations affecting BRAF

4.1. BRAF copy number gain

4.2. BRAF splicing variants

5. N-RAS mutations

6. CRAF overexpression

7. MEK mutations

8. COT overexpression

9. Activation of receptor tyrosine kinases

10. Other regulators of response to MAPK inhibitors

11. Therapies to overcome MAPK inhibitor resistance

12. Conclusions

Author details

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