Modeling Tumorigenesis in Drosophila: Current Advances and Future Perspectives ( Future Aspects of Tumor Suppressor Gene )

Publication series ： Future Aspects of Tumor Suppressor Gene

Author： Fani Papagiannouli and Bernard M. Mechler

Publisher： IntechOpen‎

Publication year： 2013

E-ISBN: INT5647155686

P-ISBN(Paperback): 9789535110637

P-ISBN(Hardback): 9789535110637

Subject： Q7 Molecular Biology

Keyword：分子生物学

Language： ENG

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Modeling Tumorigenesis in Drosophila: Current Advances and Future Perspectives

Chapter

Chapter 5 Modeling Tumorigenesis in Drosophila: Current Advances and Future Perspectives

1. Introduction

1.1. Tumor suppressor genes, a historical perspective

1.1.1. Identification of the first tumor suppressor genes in Drosophila melanogaster

2. Drosophila as a unique model system to study tumor suppression

2.1. Drosophila in a century of “tool-building” research

2.2. Drosophila is a model system relevant to human biology

3. Recent advances in modeling tumor progression and metastasis in Drosophila melanogaster

3.1. Modeling cell competition and metastasis

3.2. Drosophila provides critical insights on how conserved mechanisms contribute in cancer and tumorous development

4. New perspectives in modeling tumorigenesis in Drosophila melanogaster

5. Limitations in using Drosophila as a model system: how far can we go?

6. The expanding role of Drosophila in cancer research: Bridging past, present and future

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References

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