Hematopoietic Stem Cells in Chronic Myeloid Leukemia ( Stem Cell Biology in Normal Life and Diseases )

Publication series ： Stem Cell Biology in Normal Life and Diseases

Author： Antonieta Chávez-González Sócrates Avilés-Vázquez DafneMoreno-Lorenzana and Héctor Mayani  

Publisher： IntechOpen‎

Publication year： 2013

E-ISBN: INT4617354651

P-ISBN(Paperback): 9789535111078

P-ISBN(Hardback):  9789535111078

Subject： Q2 Cytobiology

Keyword： 细胞生物学

Language： ENG

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Hematopoietic Stem Cells in Chronic Myeloid Leukemia

Chapter

Chapter 8 Hematopoietic Stem Cells in Chronic Myeloid Leukemia

1. Introduction

2. Chronic myeloid leukemia

2.1. Epidemiology and clinical characteristics

2.2. Molecular events (Bcr-Abl oncogene)

2.3. Leukemic Stem Cells in chronic myeloid leukemia

3. Functional characteristic of leukemic stem cells in CML

3.1. Proliferation

3.2. Inhibition of apoptosis

3.3. Altered adhesion properties

3.4. Self-renewal

4. Current therapies

4.1. Interferon-α

4.2. Tyrosine kinase inhibitors

4.3. Hematopoietic cell transplant

4.4. Other agents

5. TKI resistance mechanisms

5.1. Bcr-Abl-dependent resistance mechanisms

5.2. BCR-ABL-independent resistance mechanisms

6. Concluding remarks

Author details

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