Pleiotropic Functions of HTLV-1 Tax Contribute to Cellular Transformation ( T-Cell Leukemia - Characteristics, Treatment and Prevention )

Publication series ： T-Cell Leukemia - Characteristics, Treatment and Prevention

Author： Kendle Pryor and Susan J. Marriott

Publisher： IntechOpen‎

Publication year： 2013

E-ISBN: INT4599754787

P-ISBN(Paperback): 9789535109969

P-ISBN(Hardback): 9789535109969

Subject： R73 Oncology

Keyword：肿瘤学

Language： ENG

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Pleiotropic Functions of HTLV-1 Tax Contribute to Cellular Transformation

Chapter

Chapter 4 Pleiotropic Functions of HTLV-1 Tax Contribute to Cellular Transformation

1. Introduction

2. HTLV-1 epidemiology and pathogenesis

2.1. HTLV-1 genome

2.2. Transformation by HTLV-1

3. Characterization of Tax-induced tumors in transgenic mouse models

4. Molecular mechanisms of Tax mediated transformation

4.1. Regulation of CREB and NFκB pathways by Tax

4.2. CREB and NF-κB pathways in Tax-mediated transformation

5. Effect of Tax on genome stability

5.1. Disruption of DNA repair pathways by Tax

5.2. Impact of Tax on cell cycle regulation

6. Conclusions and perspectives

Author details

References

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