Dipeptidyl Peptidase-IV and Related Proteases in Brain Tumors ( Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications )

Publication series ： Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications

Author： Petr Busek and Aleksi Sedo  

Publisher： IntechOpen‎

Publication year： 2013

E-ISBN: INT5019853888

P-ISBN(Paperback): 9789535109891

P-ISBN(Hardback):  9789535109891

Subject： R73 Oncology

Keyword： 肿瘤学

Language： ENG

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Dipeptidyl Peptidase-IV and Related Proteases in Brain Tumors

Chapter

Chapter 8 Dipeptidyl Peptidase-IV and Related Proteases in Brain Tumors

1. Introduction

2. Expression and function of dipeptidyl peptidase-IV and related proteases in the microenvironment of human malignancies

2.1. Expression in transformed cells- tumor type specific and context dependent functions

2.2. Expression and role of dipeptidyl peptidase-IV and related proteases in the stromal compartment of tumors

3. Dipeptidyl peptidase-IV and related proteases in the pathogenesis of brain tumors

3.1. Expression of DPP-IV and related proteases in glioma cell lines

3.2. Expression of DPP-IV and related proteases in normal brain and human astrocytic tumors

3.3. Possible functions of DPP-IV and FAP in the glioma microenvironment

3.3.1. DPP-IV as a possible regulator of glioma cell growth

3.3.2. Implications of FAP for glioma migration, ECM remodeling and angiogenesis

4. DPP-IV and FAP as possible markers and treatment targets in gliomas?

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