Risk Factors for Down Syndrome Birth: Understanding the Causes from Genetics and Epidemiology ( Down Syndrome )

Publication series ： Down Syndrome

Author： Sujay Ghosh and Subrata Kumar Dey  

Publisher： IntechOpen‎

Publication year： 2013

E-ISBN: INT4600952903

P-ISBN(Paperback): 9789535110361

P-ISBN(Hardback):  9789535110361

Subject： R394 medical genetics

Keyword： 医学遗传学

Language： ENG

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Risk Factors for Down Syndrome Birth: Understanding the Causes from Genetics and Epidemiology

Chapter

Chapter 9 Risk Factors for Down Syndrome Birth: Understanding the Causes from Genetics and Epidemiology

1. Introduction

2. Genetic risk factors

2.1. Advanced maternal age and related hypotheses

2.2. Altered pattern of recombination and its interaction with maternal age

2.3. Genetic polymorphism and increasing susceptibility of Down syndrome birth

2.4. Paternal risk factor for chromosome 21 nondisjunction

3. Habitual risk factor for chromosome 21 nondisjunction

4. Epidemiology of environmental pollutants associated with Down syndrome birth

5. Future research

Acknowledgements

Author details

References

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