To Grow, Stop or Die? – Novel Tumor-Suppressive Mechanism Regulated by the Transcription Factor E2F ( Future Aspects of Tumor Suppressor Gene )

Publication series ： Future Aspects of Tumor Suppressor Gene

Author： Eiko Ozono Shoji Yamaoka and Kiyoshi Ohtani  

Publisher： IntechOpen‎

Publication year： 2013

E-ISBN: INT5647154510

P-ISBN(Paperback): 9789535110637

P-ISBN(Hardback):  9789535110637

Subject： Q7 Molecular Biology

Keyword： 分子生物学

Language： ENG

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To Grow, Stop or Die? – Novel Tumor-Suppressive Mechanism Regulated by the Transcription Factor E2F

Chapter

Chapter 2 To Grow, Stop or Die? – Novel Tumor-Suppressive Mechanism Regulated by the Transcription Factor E2F

1. Introduction

2. Major tumor-suppressor pathways

2.1. The RB pathway (CDK inhibitor–Cyc/CDK–RB)

2.2. The p53 pathway (ARF–p53–cell cycle arrest or apoptosis related effectors)

2.3. The TAp73 pathway (E2F–TAp73–pro-apoptotic targets)

3. The transcription factor E2F

3.1. E2F family members

3.2. Regulatory mechanism of E2F

3.3. E2F target genes

4. Deregulated E2F

4.1. Atypical E2F targets

4.2. Distinct transcriptional regulatory mechanism mediated by deregulated E2F

4.3. Difference between deregulated E2F and physiologically activated E2F

5. Conclusion and further research

Author details

References

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