Cellular Immunotherapy Using Dendritic Cells in Multiple Myeloma: New Concept to Enhance Efficacy ( Multiple Myeloma - A Quick Reflection on the Fast Progress )

Publication series ： Multiple Myeloma - A Quick Reflection on the Fast Progress

Author： Je-Jung Lee Youn-Kyung Lee Hyun Ju Lee Sung-Hoon Jung and Thanh-Nhan Nguyen-Pham  

Publisher： IntechOpen‎

Publication year： 2013

E-ISBN: INT5651554100

P-ISBN(Paperback): 9789535110835

P-ISBN(Hardback):  9789535110835

Subject： R55 Blood and lymphatic system disorders

Keyword： 血液及淋巴系疾病

Language： ENG

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Cellular Immunotherapy Using Dendritic Cells in Multiple Myeloma: New Concept to Enhance Efficacy

Chapter

Chapter 9 Cellular Immunotherapy Using Dendritic Cells in Multiple Myeloma: New Concept to Enhance Efficacy

1. Introduction

2. Dendritic cell in myeloma immunity

3. Current DC vaccination research in MM

3.1. Idiotype-pulsed DCs

3.2. Myeloma-associated antigens-based DC immunotherapy

4. New concepts to enhance the efficacy of cellular immunotherapy in MM

4.1. How to enhance the efficacy of DC vaccinations

4.2. The next generation of DCs

4.3. New sources of myeloma-associated antigens for DC vaccines

4.4. Blocking immunosuppressive activity during the loading of tumor antigens for DC vaccines

5. Combination therapy: New concept to enhance efficacy of DC vaccines

5.1. DC vaccine and cytokine combination

5.2. DC vaccine and chemotherapy combination

5.3. Chemotherapeutic agent can induce “immunogenic myeloma-cell death” to trigger activation of DCs and to enhance cross-presentation of DCs

5.4. Possible combination DCs and other approaches

6. Future perspectives

Author details

References

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