Chromatin Remodeling in DNA Damage Response and Human Aging ( Chromatin Remodelling )

Publication series ： Chromatin Remodelling

Author： Lili Gong Edward Wang and Shiaw-Yih Lin  

Publisher： IntechOpen‎

Publication year： 2013

E-ISBN: INT5081555272

P-ISBN(Paperback): 9789535110873

P-ISBN(Hardback):  9789535110873

Subject： R394 medical genetics

Keyword： 医学遗传学

Language： ENG

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Chromatin Remodeling in DNA Damage Response and Human Aging

Chapter

Chapter 7 Chromatin Remodeling in DNA Damage Response and Human Aging

1. Introduction

2. DNA damage response

2.1. Sources leading to DNA damage

2.2. DDR pathway

2.3. DNA damage repair

3. Chromatin remodeling during DNA damage

3.1. H2AX phosphorylation

3.2. Poly(ADP-ribosyl)ation

3.3. Sumoylation

4. DNA damage processed in heterochromatin

4.1. The heterochromatin feature

4.2. The functions of heterochromatin

4.3. Detection of DSBs in heterochromatin: focusing on γH2A foci

4.4. DSBs repair in heterochromatin

5. Human aging and chromatin remodeling

5.1. Heterochromatin defects in human aging

5.2. Molecular mechanisms underlying heterochromatin loss and aging

5.3. DNA damage and human aging

6. Conclusions

Author details

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