Synthesis and Pharmacological Evaluation of K_ATP-channel Openers Related to Cromakalim: Introduction of Arylsulphonylurea Moieties

Author： Khelili S. Lebrun P. Delarge J. Pirotte B.

Publisher： Pharmaceutical Press

ISSN： 1460-8081

Source： Pharmacy and Pharmacology Communications, Vol.5, Iss.3, 1999-03, pp. : 189-193

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Abstract

A series of 4-(arylsulphonylaminocarbonylamino)-3,4-dihydro-2,2-dimethyl-2 H-1-benzopyran derivatives were prepared and evaluated as potential ATP-sensitive potassium-channel activators.Pharmacological studies showed that some compounds expressed vasodilator efficacy on vascular smooth muscle. The compounds had no inhibitory activity on insulin secretion from pancreatic β-cells.

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