Biomedical Natural Language Processing ( Natural Language Processing )

Publication series : Natural Language Processing

Author: Kevin Bretonnel Cohen   Dina Demner-Fushman  

Publisher: John Benjamins Publishing Company‎

Publication year: 2014

E-ISBN: 9789027271068

P-ISBN(Paperback): 9789027249975

Subject: H087 mathematical linguistic

Language: ENG

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[…] a great job of distilling a huge amount of work!

Chapter

2.2 The emergence of the biological domain

2.2 The emergence of the biological domain

2.3 Clinical text mining

2.3 Clinical text mining

2.4 Types of users of biomedical NLP systems

2.4 Types of users of biomedical NLP systems

2.5 Resources and tools

2.5 Resources and tools

US National Library of Medicine

US National Library of Medicine

MEDLINE database

MEDLINE database

Medical Subject Headings

Medical Subject Headings

PubMed

PubMed

GENIA

GENIA

PubMed Central International

PubMed Central International

2.6 Legal and ethical issues

2.6 Legal and ethical issues

2.7 Is biomedical natural language processing effective?

2.7 Is biomedical natural language processing effective?

3. Named entity recognition

3. Named entity recognition

3.1 Overview

3.1 Overview

3.2 The crucial role of named entity recognition in BioNLP tasks

3.2 The crucial role of named entity recognition in BioNLP tasks

3.3 Why gene names are the way they are

3.3 Why gene names are the way they are

3.4 An example of a rule-based gene NER system: KeX/PROPER

3.4 An example of a rule-based gene NER system: KeX/PROPER

3.5 An example of a statistical disease NER system

3.5 An example of a statistical disease NER system

3.6 Evaluation

3.6 Evaluation

4. Relation extraction

4. Relation extraction

4.1 Introduction

4.1 Introduction

4.1.1 Protein-protein interactions as an information extraction target

4.1.1 Protein-protein interactions as an information extraction target

4.2 Binarity of most biomedical information extraction systems

4.2 Binarity of most biomedical information extraction systems

4.3 Beyond simple binary relations

4.3 Beyond simple binary relations

4.4 Rule-based systems

4.4 Rule-based systems

4.4.1 Co-occurrence

4.4.1 Co-occurrence

4.4.2 Example rule-based systems

4.4.2 Example rule-based systems

4.4.3 Machine learning systems

4.4.3 Machine learning systems

4.5 Relations in clinical narrative

4.5 Relations in clinical narrative

4.5.1 MedLEE

4.5.1 MedLEE

4.6 SemRep

4.6 SemRep

4.6.1 NegEX

4.6.1 NegEX

4.7 Evaluation

4.7 Evaluation

5. Information retrieval/document classification

5. Information retrieval/document classification

5.1 Background

5.1 Background

5.1.1 Growth in the biomedical literature

5.1.1 Growth in the biomedical literature

5.1.2 PubMed/MEDLINE

5.1.2 PubMed/MEDLINE

5.2 Issues

5.2 Issues

5.3 A knowledge-based system that disambiguates gene names

5.3 A knowledge-based system that disambiguates gene names

5.4 A phrase-based search engine, with term and concept expansion and probabilistic relevance rankin

5.4 A phrase-based search engine, with term and concept expansion and probabilistic relevance rankin

5.5 Full text

5.5 Full text

5.6 Image and figure search

5.6 Image and figure search

5.7 Captions

5.7 Captions

5.7.1 Evaluation

5.7.1 Evaluation

6. Concept normalization

6. Concept normalization

6.1 Gene normalization

6.1 Gene normalization

6.1.1 The BioCreative definition of the gene normalization task

6.1.1 The BioCreative definition of the gene normalization task

6.2 Building a successful gene normalization system

6.2 Building a successful gene normalization system

6.2.1 Coordination and ranges

6.2.1 Coordination and ranges

6.2.2 An example system

6.2.2 An example system

6.3 Normalization and extraction of clinically pertinent terms

6.3 Normalization and extraction of clinically pertinent terms

6.3.1 MetaMap UMLS mapping tools

6.3.1 MetaMap UMLS mapping tools

7. Ontologies and computational lexical semantics

7. Ontologies and computational lexical semantics

7.1 Unified Medical Language System (UMLS)

7.1 Unified Medical Language System (UMLS)

7.1.1 The Gene Ontology

7.1.1 The Gene Ontology

7.2 Recognizing ontology terms in text

7.2 Recognizing ontology terms in text

7.3 NLP for ontology quality assurance

7.3 NLP for ontology quality assurance

7.4 Mapping, alignment, and linking of ontologies

7.4 Mapping, alignment, and linking of ontologies

8. Summarization

8. Summarization

8.1 Medical summarization systems

8.1 Medical summarization systems

8.1.1 Overview of medical summarization systems

8.1.1 Overview of medical summarization systems

8.1.2 A representative medical summarization system: Centrifuser

8.1.2 A representative medical summarization system: Centrifuser

8.2 Genomics summarization systems

8.2 Genomics summarization systems

8.2.1 Sentence selection for protein-protein interactions

8.2.1 Sentence selection for protein-protein interactions

8.2.2 EntrezGene SUMMARY field generation

8.2.2 EntrezGene SUMMARY field generation

9. Question-answering

9. Question-answering

9.1 Principles

9.1 Principles

9.1.1 Question analysis and formal representation

9.1.1 Question analysis and formal representation

9.1.1.1 Clinical questions

9.1.1.1 Clinical questions

9.1.2 Formal representation of questions

9.1.2 Formal representation of questions

9.1.3 Domain model-based question representation

9.1.3 Domain model-based question representation

9.1.3.1 Genomics and translational research questions

9.1.3.1 Genomics and translational research questions

9.1.4 Answer retrieval

9.1.4 Answer retrieval

9.1.5 Answer extraction and generation

9.1.5 Answer extraction and generation

9.1.5.1 Reference answer formats for clinical questions

9.1.5.1 Reference answer formats for clinical questions

9.1.5.2 Entity-extraction approaches to answer generation

9.1.5.2 Entity-extraction approaches to answer generation

9.2 Applications

9.2 Applications

9.2.1 Question analysis and query formulation

9.2.1 Question analysis and query formulation

9.2.2 Knowledge Extraction

9.2.2 Knowledge Extraction

9.2.2.1 Population Extractor

9.2.2.1 Population Extractor

9.2.2.2 Problem Extractor

9.2.2.2 Problem Extractor

9.2.2.3 Intervention Extractor

9.2.2.3 Intervention Extractor

9.2.2.4 Outcome Extractor

9.2.2.4 Outcome Extractor

9.2.2.5 Clinical Task classification

9.2.2.5 Clinical Task classification

9.2.2.6 Strength of Evidence classification

9.2.2.6 Strength of Evidence classification

9.2.2.7 Document scoring and ranking

9.2.2.7 Document scoring and ranking

9.2.3 Question-Document frame matching (PICO score)

9.2.3 Question-Document frame matching (PICO score)

9.2.3.1 Answer generation

9.2.3.1 Answer generation

9.2.4 Semantic clustering

9.2.4 Semantic clustering

Summary

Summary

10. Software engineering

10. Software engineering

10.1 Introduction

10.1 Introduction

10.2 Principles

10.2 Principles

10.3 General software testing

10.3 General software testing

10.3.1 Clean and dirty tests

10.3.1 Clean and dirty tests

10.3.2 Testing requires planning

10.3.2 Testing requires planning

10.3.3 Catalogues

10.3.3 Catalogues

10.3.4 How many tests are possible?

10.3.4 How many tests are possible?

10.3.5 Equivalence classes

10.3.5 Equivalence classes

10.3.6 Boundary conditions

10.3.6 Boundary conditions

10.4 Code coverage

10.4 Code coverage

10.5 When your input is language

10.5 When your input is language

10.6 User interface evaluation

10.6 User interface evaluation

10.6.1 API interface usability

10.6.1 API interface usability

11. Corpus construction and annotation

11. Corpus construction and annotation

11.1 Corpora in the two domains as driving forces of research

11.1 Corpora in the two domains as driving forces of research

11.2 Who should build biomedical corpora?

11.2 Who should build biomedical corpora?

11.3 The relationship between annotation of entities and annotation of linguistic structure

11.3 The relationship between annotation of entities and annotation of linguistic structure

11.4 Commonly used biomedical corpora

11.4 Commonly used biomedical corpora

11.4.1 GENIA

11.4.1 GENIA

11.4.2 CRAFT

11.4.2 CRAFT

11.4.3 BioCreative gene mention corpora

11.4.3 BioCreative gene mention corpora

11.4.4 AIMed

11.4.4 AIMed

11.4.5 Word sense disambiguation

11.4.5 Word sense disambiguation

11.4.6 Clinical corpora

11.4.6 Clinical corpora

11.4.6.1 NLP Challenge

11.4.6.1 NLP Challenge

11.4.6.2 The MIMIC collection

11.4.6.2 The MIMIC collection

11.5 Factors that contribute to the success of biomedical corpora

11.5 Factors that contribute to the success of biomedical corpora

References

References

Index

Index

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