Chapter
PART 1: ENERGY METABOLISM, PHOTOSYNTHESIS, FERMENTATION
PART 1: ENERGY METABOLISM, PHOTOSYNTHESIS, FERMENTATION
Chapter 2. The Role of Lactic Acid in the Development of Biochemistry
Chapter 2. The Role of Lactic Acid in the Development of Biochemistry
SOURCE OF ENERGY FOR MUSCULAR WORK
SOURCE OF ENERGY FOR MUSCULAR WORK
Chapter 3. Origins of the Concept of Oxidative Phosphorylation: Retrospectives and Perspectives
Chapter 3. Origins of the Concept of Oxidative Phosphorylation: Retrospectives and Perspectives
THE P/O RATIOS IN VARIOUS TISSUES
THE P/O RATIOS IN VARIOUS TISSUES
"ENERGIZED STATE" OF MEMBRANES
"ENERGIZED STATE" OF MEMBRANES
Chapter 4. Reflections on the Evolutionary Transition from Prokaryotes to Eukaryotes
Chapter 4. Reflections on the Evolutionary Transition from Prokaryotes to Eukaryotes
SOME RELEVANT EXAMPLES OF PRESENT-DAY SYMBIOSIS
SOME RELEVANT EXAMPLES OF PRESENT-DAY SYMBIOSIS
BACTERIAL ASSOCIATION WITH EUKARYOTE CELLS
BACTERIAL ASSOCIATION WITH EUKARYOTE CELLS
Chapter 5. A Pathway from Psychiatry to Cancer
Chapter 5. A Pathway from Psychiatry to Cancer
Chapter 6. Bioenergetics: Past, Present and Future
Chapter 6. Bioenergetics: Past, Present and Future
Chapter 7. Enzymes Revisited
Chapter 7. Enzymes Revisited
ALCOHOL DEHYDROGENASE IN 1955
ALCOHOL DEHYDROGENASE IN 1955
ALCOHOL DEHYDROGENASES REVISITED TWENTY YEARS LATER
ALCOHOL DEHYDROGENASES REVISITED TWENTY YEARS LATER
CYTOCHROME c REVISITED TWENTY YEARS LATER
CYTOCHROME c REVISITED TWENTY YEARS LATER
Chapter 8. Unravelling the Pentose Phosphate Pathway
Chapter 8. Unravelling the Pentose Phosphate Pathway
Chapter 9. Reducing Power and the Regulation of Photosynthesis
Chapter 9. Reducing Power and the Regulation of Photosynthesis
PATHWAYS OF CARBON, NITROGEN AND SULFUR PHOTOSYNTHETIC REDUCTION
PATHWAYS OF CARBON, NITROGEN AND SULFUR PHOTOSYNTHETIC REDUCTION
REGULATION OF THE PHOTOSYNTHETIC PATHWAYS OF CARBON AND NITROGEN ASSIMILATION
REGULATION OF THE PHOTOSYNTHETIC PATHWAYS OF CARBON AND NITROGEN ASSIMILATION
Chapter 10. Studies on High-Energy Phosphate Bonds: From Biosynthetic to Mechanochemical Reactions
Chapter 10. Studies on High-Energy Phosphate Bonds: From Biosynthetic to Mechanochemical Reactions
N.Y.U. AND PROPIONYL-CoA CARBOXYLASE
N.Y.U. AND PROPIONYL-CoA CARBOXYLASE
STUDIES ON THE POLYPEPTIDE CHAIN ELONGATION AND A CHALLENGE TO MECHANOCHEMICAL REACTIONS
STUDIES ON THE POLYPEPTIDE CHAIN ELONGATION AND A CHALLENGE TO MECHANOCHEMICAL REACTIONS
Chapter 11. Glutamate Fermentation and the Discovery of B12 Coenzymes
Chapter 11. Glutamate Fermentation and the Discovery of B12 Coenzymes
Chapter 12. Trailing the Propionic Acid Bacteria
Chapter 12. Trailing the Propionic Acid Bacteria
Chapter 13. Biosynthesis of Cell Components from Acetate
Chapter 13. Biosynthesis of Cell Components from Acetate
Chapter 14. Lessons in Learning
Chapter 14. Lessons in Learning
III. CHEMISTRY-BIOLOGY BRIDGE
III. CHEMISTRY-BIOLOGY BRIDGE
IV. GENETICS AND PHYSICS PROBE
IV. GENETICS AND PHYSICS PROBE
Chapter 15. The Impact of the ATP-Generating Systems
Chapter 15. The Impact of the ATP-Generating Systems
PART II: LIPIDS, SACCHARIDES, CELL WALLS
PART II: LIPIDS, SACCHARIDES, CELL WALLS
Chapter 16. On the Evolution of a Biosynthetic Pathway
Chapter 16. On the Evolution of a Biosynthetic Pathway
STEROLS AND THE PROCARYOTIC-EUCARYOTIC TRANSITION
STEROLS AND THE PROCARYOTIC-EUCARYOTIC TRANSITION
Chapter 17. My Expeditions into Sulfur Biochemistry
Chapter 17. My Expeditions into Sulfur Biochemistry
Chapter 18. The Clostridium kluyveri–Acetyl-CoA Epoch
Chapter 18. The Clostridium kluyveri–Acetyl-CoA Epoch
Chapter 19. Biotin Unmasked
Chapter 19. Biotin Unmasked
Chapter 20. The Seven Veils of Dipicolinic Acid
Chapter 20. The Seven Veils of Dipicolinic Acid
Chapter 21. Enzymic Mechanisms Involved in the Synthesis of Yeast Cell Wall
Chapter 21. Enzymic Mechanisms Involved in the Synthesis of Yeast Cell Wall
STRUCTURE OF SACCHAROMYCES CEREVISIAE WALL
STRUCTURE OF SACCHAROMYCES CEREVISIAE WALL
BIOSYNTHESIS OF SACCHAROMYCES CEREVISIAE WALL: FORMATION OF WALL GLYCOPROTEIN(S)
BIOSYNTHESIS OF SACCHAROMYCES CEREVISIAE WALL: FORMATION OF WALL GLYCOPROTEIN(S)
FORMATION OF THE CARBOHYDRATE MOIETY OF WALL GLYCOPROTEIN(S)
FORMATION OF THE CARBOHYDRATE MOIETY OF WALL GLYCOPROTEIN(S)
INCORPORATION OF MANNOSE IN THE SMOOTH ENDOPLASMIC RETICULUM
INCORPORATION OF MANNOSE IN THE SMOOTH ENDOPLASMIC RETICULUM
ROLE OF LIPIDS IN GLYCOPROTEIN SYNTHESIS
ROLE OF LIPIDS IN GLYCOPROTEIN SYNTHESIS
SECRETION OF GLYCOPROTEINS
SECRETION OF GLYCOPROTEINS
REGULATION OF WALL FORMATION
REGULATION OF WALL FORMATION
Chapter 22. The Pasteur Effect in the Allosteric Era
Chapter 22. The Pasteur Effect in the Allosteric Era
Chapter 23. Comparative Aspects of Hormonal Regulation of Adipose Tissue Lipolysis
Chapter 23. Comparative Aspects of Hormonal Regulation of Adipose Tissue Lipolysis
EFFECT OF VARIOUS HORMONES ON FFA MOBILIZATION IN THE INTACT ANIMAL
EFFECT OF VARIOUS HORMONES ON FFA MOBILIZATION IN THE INTACT ANIMAL
HORMONAL EFFECTS ON THE LIPOLYTIC ACTIVITY OF ADIPOSE TISSUE INCUBATED IN VITRO
HORMONAL EFFECTS ON THE LIPOLYTIC ACTIVITY OF ADIPOSE TISSUE INCUBATED IN VITRO
PATTERNS OF CONTROL OF ADIPOSE TISSUE LIPOLYSIS
PATTERNS OF CONTROL OF ADIPOSE TISSUE LIPOLYSIS
Chapter 24. Reflections on the Relevance of Biochemistry for the Understanding of Living Systems
Chapter 24. Reflections on the Relevance of Biochemistry for the Understanding of Living Systems
I. STRUCTURAL AND METABOLIC FACTORS IN THE ORGANIZATION OF LIVING CELLS
I. STRUCTURAL AND METABOLIC FACTORS IN THE ORGANIZATION OF LIVING CELLS
II. DOMINANCE OF THE OVERALL DESIGN IN THE ORGANIZATION OF LIVING SYSTEMS
II. DOMINANCE OF THE OVERALL DESIGN IN THE ORGANIZATION OF LIVING SYSTEMS
III. THE GENOME AS A COORDINATED ASSEMBLY OF INFORMATION-PROCESSING DEVICES
III. THE GENOME AS A COORDINATED ASSEMBLY OF INFORMATION-PROCESSING DEVICES
Chapter 25. Formation and Cleavage of C—N Bonds in Arginine Biosynthesis and Urea Formation
Chapter 25. Formation and Cleavage of C—N Bonds in Arginine Biosynthesis and Urea Formation
GENERAL FEATURES OF NITROGEN TRANSFER FROM ASPARTATE IN FORMATION OF C—N BONDS
GENERAL FEATURES OF NITROGEN TRANSFER FROM ASPARTATE IN FORMATION OF C—N BONDS
MECHANISM OF GUANIDINO GROUP SYNTHESIS
MECHANISM OF GUANIDINO GROUP SYNTHESIS
HOW DOES THE UREA CYCLE OPERATE—WHAT MAKES IT RUN?
HOW DOES THE UREA CYCLE OPERATE—WHAT MAKES IT RUN?
MOLECULAR BEHAVIOR IN RELATION TO BIOLOGICAL PROCESSES
MOLECULAR BEHAVIOR IN RELATION TO BIOLOGICAL PROCESSES
HUMAN MUTATIONS AND NEW QUESTIONS
HUMAN MUTATIONS AND NEW QUESTIONS
Chapter 26. Molecular Ecology
Chapter 26. Molecular Ecology
A GLIMPSE AT THE ENVIRONMENT
A GLIMPSE AT THE ENVIRONMENT
A BRIEF ECOLOGICAL EXCURSION
A BRIEF ECOLOGICAL EXCURSION
PART IV: NUCLEIC ACIDS AND THE GENETIC CODE
PART IV: NUCLEIC ACIDS AND THE GENETIC CODE
Chapter 27. For the Love of Enzymes
Chapter 27. For the Love of Enzymes
NUCLEOTIDE PYROPHOSPHATASE
NUCLEOTIDE PYROPHOSPHATASE
POLYNUCLEOTIDE PHOSPHORYLASE
POLYNUCLEOTIDE PHOSPHORYLASE
OTHER REPLICATION ENZYMES
OTHER REPLICATION ENZYMES
MULTIPLE FACES OF ENZYMES
MULTIPLE FACES OF ENZYMES
Chapter 28. From Enzyme Chemistry to Genetic Manipulation
Chapter 28. From Enzyme Chemistry to Genetic Manipulation
Chapter 29. The Search for the Structural Relationship between Gene and Enzyme
Chapter 29. The Search for the Structural Relationship between Gene and Enzyme
Chapter 30. Synthesis in the Study of Nucleic Acids
Chapter 30. Synthesis in the Study of Nucleic Acids
METHODOLOGY FOR THE ORGANOCHEMICAL SYNTHESIS OF DEOXY-RIBOPOLYNUCLEOTIDES
METHODOLOGY FOR THE ORGANOCHEMICAL SYNTHESIS OF DEOXY-RIBOPOLYNUCLEOTIDES
POLYNUCLEOTIDE SYNTHESIS AND THE GENETIC CODE
POLYNUCLEOTIDE SYNTHESIS AND THE GENETIC CODE
SYNTHESIS OF tRNA GENES AND NUCLEOTIDE SEQUENCES IN THE PROMOTER REGIONS
SYNTHESIS OF tRNA GENES AND NUCLEOTIDE SEQUENCES IN THE PROMOTER REGIONS
NUCLEOTIDE SEQUENCE IN THE PROMOTER AND TERMINATOR REGIONS
NUCLEOTIDE SEQUENCE IN THE PROMOTER AND TERMINATOR REGIONS
Chapter 31. A Phage in New York
Chapter 31. A Phage in New York
Chapter 32. Bacteriophage ϕ29
Chapter 32. Bacteriophage ϕ29
PART V: PROTEIN BIOSYNTHESIS
PART V: PROTEIN BIOSYNTHESIS
Chapter 33. Protein Synthesis: Early Waves and Recent Ripples
Chapter 33. Protein Synthesis: Early Waves and Recent Ripples
Chapter 34. Ten Years in Protein Synthesis
Chapter 34. Ten Years in Protein Synthesis
STUDIES ON THE GENETIC CODE
STUDIES ON THE GENETIC CODE
STUDIES ON PEPTIDE CHAIN ELONGATION
STUDIES ON PEPTIDE CHAIN ELONGATION
STUDIES ON PEPTIDE CHAIN INITIATION
STUDIES ON PEPTIDE CHAIN INITIATION
STUDIES ON THE MOVEMENT OF THE RIBOSOME ALONG THE mRNA DURING PROTEIN SYNTHESIS
STUDIES ON THE MOVEMENT OF THE RIBOSOME ALONG THE mRNA DURING PROTEIN SYNTHESIS
Chapter 35. Bacteriophages, Colicins and Ribosomes: Some Reflections on my Research Career
Chapter 35. Bacteriophages, Colicins and Ribosomes: Some Reflections on my Research Career
Chapter 36. Ribosomes: Structure, Function and Evolution
Chapter 36. Ribosomes: Structure, Function and Evolution
RECENT LITERATURE ON RIBOSOMES
RECENT LITERATURE ON RIBOSOMES
Chapter 37. Thoughts on Polypeptide Chain Elongation
Chapter 37. Thoughts on Polypeptide Chain Elongation
Chapter 38. Twenty-five Years of Research on Inhibitors of Protein Synthesis: Prospects for Future Developments in the Subject
Chapter 38. Twenty-five Years of Research on Inhibitors of Protein Synthesis: Prospects for Future Developments in the Subject
SELECTIVE ACTION OF TRANSLATION INHIBITORS
SELECTIVE ACTION OF TRANSLATION INHIBITORS
EARLY STUDIES WITH INTACT CELLS
EARLY STUDIES WITH INTACT CELLS
THE PIONEER CELL-FREE SYSTEMS
THE PIONEER CELL-FREE SYSTEMS
EFFECTS OF INHIBITORS ON THE STEPS OF TRANSLATION
EFFECTS OF INHIBITORS ON THE STEPS OF TRANSLATION
PRESENT AND FUTURE OF RESEARCH ON INHIBITORS OF TRANSLATION
PRESENT AND FUTURE OF RESEARCH ON INHIBITORS OF TRANSLATION
PART VI: CELL BIOLOGY AND NEUROBIOLOGY
PART VI: CELL BIOLOGY AND NEUROBIOLOGY
Chapter 39. A Biochemist Looks at the Nervous System
Chapter 39. A Biochemist Looks at the Nervous System
INBORN ERRORS OF METABOLISM
INBORN ERRORS OF METABOLISM
PERINATAL BIOCHEMISTRY: MAIN EVENTS
PERINATAL BIOCHEMISTRY: MAIN EVENTS
Chapter 40. Brain Damage and Perinatal Biochemistry
Chapter 40. Brain Damage and Perinatal Biochemistry
INBORN ERRORS OF METABOLISM
INBORN ERRORS OF METABOLISM
PERINATAL BIOCHEMISTRY: MAIN EVENTS
PERINATAL BIOCHEMISTRY: MAIN EVENTS
Chapter 41. My Interrupted Association with Potassium
Chapter 41. My Interrupted Association with Potassium
Chapter 42. A Personal Account of My Research on Collagen and Fibrosis
Chapter 42. A Personal Account of My Research on Collagen and Fibrosis
PART VII: SCIENCE IN THE TIME OF OCHOA
PART VII: SCIENCE IN THE TIME OF OCHOA
Chapter 43. Reminiscences of Severo Ochoa from our Oxford Days
Chapter 43. Reminiscences of Severo Ochoa from our Oxford Days
Chapter 44. Highlights of a Friendship
Chapter 44. Highlights of a Friendship
Chapter 45. Discovery Made Easy
Chapter 45. Discovery Made Easy
Chapter 46. Comments on the Productivity of Scientists
Chapter 46. Comments on the Productivity of Scientists
DIFFERENCES IN THE PREREQUISITES OF PRODUCTIVITY IN ARTS AND SCIENCES
DIFFERENCES IN THE PREREQUISITES OF PRODUCTIVITY IN ARTS AND SCIENCES
DISTRACTION FROM PRODUCTIVITY IN SCIENCE
DISTRACTION FROM PRODUCTIVITY IN SCIENCE
AGE AND QUALITY OF RESEARCH
AGE AND QUALITY OF RESEARCH
ORIGINS OF CONTINUED PRODUCTIVITY IN SCIENCE
ORIGINS OF CONTINUED PRODUCTIVITY IN SCIENCE
THE ARCHITECTS AND THE WORKMEN
THE ARCHITECTS AND THE WORKMEN
Chapter 47. Prebiological Chemistry and the Origin of Life: A Personal Account
Chapter 47. Prebiological Chemistry and the Origin of Life: A Personal Account
SEVERO OCHOA, NEW YORK, 1952
SEVERO OCHOA, NEW YORK, 1952
PREBIOTIC SYNTHESIS OF BIOCHEMICAL COMPOUNDS—SCOPE OF ESSAY
PREBIOTIC SYNTHESIS OF BIOCHEMICAL COMPOUNDS—SCOPE OF ESSAY
AMINO ACIDS FROM ONE-CARBON COMPOUNDS
AMINO ACIDS FROM ONE-CARBON COMPOUNDS
A PREBIOTIC ROUTE FOR PURINE SYNTHESIS
A PREBIOTIC ROUTE FOR PURINE SYNTHESIS
ADENINE FROM HCN: FROM POISON TO LIFE GIVER
ADENINE FROM HCN: FROM POISON TO LIFE GIVER
ADENINE AND OTHER PURINES: MECHANISMS AND YIELDS
ADENINE AND OTHER PURINES: MECHANISMS AND YIELDS
A PREBIOTIC PANDORA'S BOX
A PREBIOTIC PANDORA'S BOX
FORMATION OF RIBOSE AND DEOXYRIBOSE
FORMATION OF RIBOSE AND DEOXYRIBOSE
CYANAMIDE. A PREBIOTIC ANALOG OF DICYCLOHEXYLCARBODIIMIDE
CYANAMIDE. A PREBIOTIC ANALOG OF DICYCLOHEXYLCARBODIIMIDE
OLIGODEOXYRIBONUCLEOTIDES
OLIGODEOXYRIBONUCLEOTIDES
PREBIOTIC SYNTHESIS OF PEPTIDES
PREBIOTIC SYNTHESIS OF PEPTIDES
A UNIFIED SYSTEM FOR THE PREBIOTIC SYNTHESIS OF OLIGOMERS
A UNIFIED SYSTEM FOR THE PREBIOTIC SYNTHESIS OF OLIGOMERS
BASE-PAIR-DIRECTED SYNTHESIS OF OLIGONUCLEOTIDES
BASE-PAIR-DIRECTED SYNTHESIS OF OLIGONUCLEOTIDES
CYCLIC CHANGES IN PREBIOTIC ENVIRONMENTS
CYCLIC CHANGES IN PREBIOTIC ENVIRONMENTS
ELONGATION AND REPLICATION OF OLIGONUCLEOTIDES
ELONGATION AND REPLICATION OF OLIGONUCLEOTIDES
MAJOR EVOLUTIONARY TRANSITIONS
MAJOR EVOLUTIONARY TRANSITIONS
PROTOBIOLOGICAL OR PRECELLULAR EVOLUTION
PROTOBIOLOGICAL OR PRECELLULAR EVOLUTION
EXPERIMENTAL AND THEORETICAL MODELS OF PRECELLULAR EVOLUTION
EXPERIMENTAL AND THEORETICAL MODELS OF PRECELLULAR EVOLUTION
EPILOG (THE CYCLE OF LIFE AND MATTER)
EPILOG (THE CYCLE OF LIFE AND MATTER)
My Homage to Severo Ochoa
My Homage to Severo Ochoa
Reflections on Biochemistry
：In Honour of Severo Ochoa
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