Publication subTitle :Current Status and New Developments
Author: Prestayko Archie W.;Baker Laurence H.;Crooke Stanley T.
Publisher: Elsevier Science
Publication year: 2013
E-ISBN: 9781483219448
P-ISBN(Paperback): 9780125650601
Subject: R730.53 Chemical therapy (drug)
Keyword: 化学
Language: ENG
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Description
Nitrosoureas: Current Status and New Developments covers the preclinical and clinical status of nitrosoureas. The book presents preclinical studies on the development of the nitrosoureas; combination chemotherapy with nitrosoureas plus other anticancer drugs against animal tumors; EORTC studies with novel nitrosoureas; and chemical decomposition of chloroethylnitrosoureas.
The text also includes preclinical studies on the metabolism of nitrosoureas; DNA crosslinking and the origin of sensitivity to chloroethylnitrosoureas; modification of DNA and RNA bases; and carbamoylating activity of nitrosoureas. Clinical studies on subacute and chronic toxicities associated with nitrosourea therapy; the toxicity of high-dose BCNU with autologous marrow support; and the clinical pharmacology of the nitrosoureas are also considered. The book further tackles clinical studies on nitrosoureas in the therapy of Hodgkin's disease; nitrosourea-containing combinations in small-cell lung cancer; adjuvant therapy of brain tumors with nitrosoureas; and clinical use of nitrosoureas in gastrointestinal cancer.
Oncologists, toxicologists, biochemists, pharmacologists, and other scientists working in drug development will find the text invaluable.