Publisher： Spandidos Publications
E-ISSN： 1792-1015|10|3|1025-1028
ISSN： 1792-0981
Source： Experimental and Therapeutic Medicine, Vol.10, Iss.3, 2015-01, pp. : 1025-1028
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Systemic Epstein-Barr virus (EBV)-positive T-cell lymphoproliferative disease (EBV+ T-LPD) occurs mainly in Asia and South America and is extremely rare in adults. The disease is characterized by a clonal proliferation of EBV-infected T cells with a cytotoxic immunophenotype and is associated with a poor clinical outcome and can be lifethreatening. The majority of the patients have evidence of systemic disease, often with lymph node, liver and spleen involvement. The present study describes a case of adult systemic EBV+ TLPD with high fever, systemic lymphadenopathy, hepatosplenomegaly, nose-pharynx neoplasm, pancytopenia, EB virus infection and proliferative bone marrow, with the aim of improving the understanding of the condition.
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