Transient Effect of Granulocyte Colony-Stimulating Factor in Allo-Immune Neonatal Neutropenia

Publisher: Karger

E-ISSN: 1661-7819|78|4|277-280

ISSN: 1661-7800

Source: Neonatology, Vol.78, Iss.4, 2000-11, pp. : 277-280

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Abstract

The effect of recombinant human granulocyte colony-stimulating factor (rhG-CSF) administration at 10 μg/kg/day for 15–30 min over 3 consecutive days in 3 preterm neonates with allo-immune neonatal neutropenia (ANN) is reported. Patients 1 and 2 had antibodies against antigen NA2, while patient 3 had antibodies against NA1. All neonates developed a rapid increase in absolute neutrophil count which reached the normal range within 48 h (from 75–640/mm3 to 2,520–4,700/mm3). However, 23–25 days later, all 3 neonates relapsed into a second phase of severe neutropenia (408–870/mm3). Antibodies against neutrophil antigens were still positive during this period. This second-phase neutropenia persisted for 20–30 days and resolved spontaneously. It may be possible that when rhG-CSF is administered within a short time after birth in neonates with ANN, its effect is exhausted before the concentration of circulating antibodies decreases, with the result that a second phase of neutropenia can be expected.

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