Publisher: Karger
E-ISSN: 1421-9867|72|4|229-238
ISSN: 0012-2823
Source: Digestion, Vol.72, Iss.4, 2005-12, pp. : 229-238
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Approximately three quarters of individuals who suffer from gastroesophageal reflux disease (GERD) experience its symptoms at night. Nighttime GERD symptoms disturb sleep and diminish quality of life more so than daytime symptoms. Nighttime gastroesophageal reflux is common in individuals with respiratory disorders such as sleep apnea and asthma, and may affect the severity and the frequency of these disorders. The treatments of choice for nighttime GERD symptoms are proton pump inhibitors (PPIs) due to their efficacy in relieving day- and nighttime GERD symptoms and controlling acid secretion. The onset of action, degree of acid suppression, and duration of effect of PPIs have important implications for the use of these therapies in clinical practice. PPIs that exhibit rapid and prolonged control of acid secretion may be particularly useful for treating nighttime GERD symptoms.
Related content
Nighttime Heartburn in Patients with Gastroesophageal Reflux Disease under Routine Care
Digestion, Vol. 77, Iss. 2, 2008-03 ,pp. :
Treatment of Gastroesophageal Reflux Disease in Adults: An Individualized Approach
Digestive Diseases, Vol. 22, Iss. 2, 2004-09 ,pp. :
A Prokinetic Approach to Treatment of Gastroesophageal Reflux Disease
Digestive Diseases, Vol. 16, Iss. 1, 1998-02 ,pp. :
Treatment of Gastroesophageal Reflux Disease: Endoscopic Aspects
Digestive Diseases, Vol. 25, Iss. 3, 2007-09 ,pp. :