Publisher: Karger
E-ISSN: 1421-9913|42|1|27-35
ISSN: 0014-3022
Source: European Neurology, Vol.42, Iss.1, 1999-07, pp. : 27-35
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
The aim of this study was to assess effect of long-term oxygen therapy (LTOT) on the function of central and autonomic nervous system in patients with hypoxaemic chronic obstructive pulmonary disease (COPD). A battery of neuropsychological tests was used together with the Short Test of Mental Status in addition to transcranial Doppler ultrasonography, and five cardiovascular tests as well as a questionnaire on autonomic function. Ten COPD patients, 4 males and 6 females, with a mean age of 65.9 ± 7.3 (SD) years, were studied at the beginning and after 3 months of LTOT. At start PaO2 was 6.7 ± 1.1 kPa without oxygen and 9.9 ± 1.5 kPa after 3 months with oxygen. Our results demonstrate that neuropsychological function, cerebral blood flow velocity and autonomic function were positively influenced after 3 months of LTOT although the changes did not reach statistical significance. The COPD patients were cognitively impaired as compared to age-matched healthy controls. Our findings were consistent with the previous notion of improvement of hypoxic cognitive dysfunction by LTOT.
Related content
Screening of Cognitive Impairment in Chronic Obstructive Pulmonary Disease
Dementia and Geriatric Cognitive Disorders, Vol. 23, Iss. 4, 2007-03 ,pp. :
Chronic Obstructive Pulmonary Disease
Medical Principles and Practice, Vol. 7, Iss. 1, 1998-04 ,pp. :