Homing Receptor Expression on Cord Blood T Lymphocytes and the Development of Atopic Eczema in Infants

Publisher: Karger

E-ISSN: 1423-0097|124|1-3|332-335

ISSN: 1018-2438

Source: International Archives of Allergy and Immunology, Vol.124, Iss.1-3, 2012-01, pp. : 332-335

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

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Abstract

Expression of the gut-homing receptor integrin αEβ7, but not cutaneous lymphocyte-associated antigen (CLA), on milk allergen-stimulated cord blood T lymphocytes precedes the development of milk-induced eczema in early infancy. The data indicate the involvement of integrin αEβ7 in the development of infantile allergic eczema and provide a clue to the avoidance of specific allergens and novel therapy targeting homing receptors in food allergy.