Publisher: Karger
E-ISSN: 2296-4657|1|3|133-140
ISSN: 2296-4681
Source: Ocular Oncology and Pathology, Vol.1, Iss.3, 2015-04, pp. : 133-140
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Animal models play a crucial role in basic and translational oncology research. Conventional rodent experiments, however, face ethical, practical and technical issues that limit their use. The chick embryo represents an accessible and economical in vivo model, which has long been used in developmental biology and for the study of angiogenesis. It is also a recognised xenograft model, and because of its lack of immune system in early development, the chick embryo has established itself as a key model system for cancer research, with which to study various steps in the metastatic process. In this chapter, we review the chick embryo model and the technical approaches adopted by cancer biologists, including advances in real-time imaging, and discuss how this has been or can be applied to improve our understanding of the biological events during uveal melanoma development and metastasis.
Related content
Molecular genetics of uveal melanoma
By Loercher Amy E. Harbour J. William
Current Eye Research, Vol. 27, Iss. 2, 2003-08 ,pp. :
Angiogenesis in Uveal Melanoma
Ophthalmic Research, Vol. 38, Iss. 5, 2006-10 ,pp. :
Culturing Uveal Melanoma Cells
Ocular Oncology and Pathology, Vol. 1, Iss. 3, 2015-04 ,pp. :