Publisher: Karger
E-ISSN: 1660-3818|38|3|173-182
ISSN: 1660-3796
Source: Transfusion Medicine and Hemotherapy, Vol.38, Iss.3, 2011-05, pp. : 173-182
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Allogeneic hematopoietic progenitor cell transplantation (HPCT) is a crucial therapeutic option in hematological malignancies, and the graft-versus-leukemia (GvL) effect builds the cornerstone of a long-lasting remission. Cytotoxic T cells are known to be the primary effector cells in GvL. They recognize minor histocompatibility antigens (mHags) and tumor/leukemia-associated antigens. In case of disease relapse after HPCT, donor lymphocyte infusion (DLI) is an important treatment option for re-induction of remission. However, both treatments, HPCT and DLI carry the risk of morbidity and mortality due to graft-versus-host disease (GvHD) and severe infections. Therefore, the development of targeted adoptive immunotherapy with a lower risk of GvHD is needed, and several study groups are working on that topic.
Related content
Bullous pemphigoid after allogeneic hematopoietic stem cell transplantation
PEDIATRICS INTERNATIONAL, Vol. 57, Iss. 3, 2015-06 ,pp. :
Atovaquone for Prophylaxis of Toxoplasmosis after Allogeneic Hematopoietic Stem Cell Transplantation
Acta Haematologica, Vol. 134, Iss. 3, 2015-05 ,pp. :