Comparison of Atlas- and Magnetic-Resonance-Imaging-Based Stereotactic Targeting of the Subthalamic Nucleus in the Surgical Treatment of Parkinson’s Disease

Publisher： Karger

E-ISSN： 1423-0372|86|3|153-161

ISSN： 1011-6125

Source： Stereotactic and Functional Neurosurgery, Vol.86, Iss.3, 2008-03, pp. : 153-161

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

Aims: To assess the variability of the subthalamic nucleus (STN) size, orientation and target coordinates from direct visualization on high-resolution magnetic resonance (MR) images in patients undergoing surgical intervention for Parkinson’s disease. Methods: Sixty-six patients with Parkinson’s disease were included in this study. The STN was visualized directly on high-resolution MR images, the size and orientation in both coronal and axial planes were recorded, as were the coordinates of the dorsolateral STN target in relation to the anterior-posterior commissural (AC-PC) line. The same STN target was defined in the Schaltenbrand atlas and atlas-based coordinates in proportion to the patient’s AC-PC dimension were calculated. MR-imaging-based STN target coordinates were compared with the corresponding atlas-based coordinates. Results: Marked variation of STN size and orientation was observed. A significant difference was demonstrated on comparing left- and right-sided x and y coordinates. The comparison between MR-imaging-based and atlas-derived target coordinates demonstrated a significant difference in all directions except the left y coordinate. Conclusions: This study demonstrates the substantial individual variability of STN size, orientation and target coordinates and a significant difference between target coordinates obtained by direct visual targeting on MR images and those obtained by indirect targeting based on atlases.

Related content

Subthalamic Nucleus Deep Brain Stimulation for Parkinson’s Disease: Magnetic Resonance Imaging Targeting Using Visible Anatomical Landmarks

By  

Stereotactic and Functional Neurosurgery, Vol. 80, Iss. 1-4, 2004-01 ,pp. : 76-81 (6)

Karger

Access to resources Recommend Favorite

Stereotactic Subthalamic Nucleus Lesioning for the Treatment of Parkinson’s Disease

By  

Stereotactic and Functional Neurosurgery, Vol. 77, Iss. 1-4, 2002-10 ,pp. : 79-86 (8)

Karger

Access to resources Recommend Favorite

Lesioning the Subthalamic Nucleus in the Treatment of Parkinson’s Disease

By  

Stereotactic and Functional Neurosurgery, Vol. 77, Iss. 1-4, 2002-10 ,pp. : 68-72 (5)

Karger

Access to resources Recommend Favorite

Stereotactic Targeting of the Subthalamic Nucleus: Relevance of Magnetic Resonance-Based Evaluation of Interindividual Variation in Diencephalic Anatomy

By  

Stereotactic and Functional Neurosurgery, Vol. 86, Iss. 5, 2008-10 ,pp. : 330-331 (2)

Karger

Access to resources Recommend Favorite

Bilateral Stimulation of the Subthalamic Nucleus in Parkinson’s Disease: Surgical Efficacy and Prediction of Outcome

By  

Stereotactic and Functional Neurosurgery, Vol. 82, Iss. 2-3, 2004-08 ,pp. : 104-114 (11)

Karger

Access to resources Recommend Favorite