Comparison of Long-Term Outcomes between Spousal Transplants and Other Living Unrelated Donor Transplants: Single-Center Experience
Publisher：
Karger
E-ISSN：
1660-2110|113|4|c241-c249
ISSN：
1660-2110
Source：
Nephron Clin Pract,
Vol.113,
Iss.4, 2009-08,
pp. : c241-c249
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Abstract
Background/Aims: The greater use of living unrelated donors (LUDs) as kidney donors is a worldwide trend in the current era of organ shortage, and spouses are an important source of LUDs. This study was to compare the long-term outcomes of spousal donor grafts with other LUD grafts. Methods: Among 445 LUD grafts, 77 were spouses and 368 were other LUDs. The clinical characteristics and long-term survival rates for spousal transplants were compared with those for other LUD transplants, and risk factors affecting graft survival were assessed. Results: Spousal donors had a significantly higher average number of human leukocyte antigen (HLA) mismatches (4.2 vs. 3.4, p < 0.001) and were older (41 vs. 33 years, p < 0.001) than LUDs. The 10-year survival rates for spousal donor grafts were 60.6%, similar to those for LUD grafts (58.5%, p = 0.61). The 10-year biopsy-proven acute rejection-free survival rates (85.5 vs. 89.6%, p = 0.45) and patient survival rates were also similar (84.3 vs. 79.6%, p = 0.35). The degree of HLA mismatching, the spousal donor type or donor age did not affect the graft survival. Conclusion: Renal transplants from spousal donors show similar long-term outcomes to those from better HLA-matched and younger LUDs.
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