Publisher： Karger
E-ISSN： 1424-859x|86|2|105-111
ISSN： 1424-8581
Source： Cytogenetic and Genome Research, Vol.86, Iss.2, 1999-10, pp. : 105-111
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Abstract
; mutations on the same inbred genetic background has confirmed the genotype-phenotype correlations initially established among FAP patients, as well as provided important insights into the mechanisms of colorectal tumor formation. Here we review the major features of the available animal models for FAP and attempt the formulation of a hypothetical model for APC-driven tumorigenesis based on the observed genetic and phenotypic variability in mouse and man.
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